Early life nutrition influences susceptibility to chronic inflammatory colitis in later life.
Aging
Animals
Animals, Newborn
Body Composition
Chronic Disease
Colitis
/ chemically induced
Cytokines
/ metabolism
Disease Models, Animal
Disease Susceptibility
Female
Gastrointestinal Microbiome
Glycosylation
Growth Disorders
Humans
Infant
Infant Nutritional Physiological Phenomena
Intestines
/ growth & development
Male
Mice, Inbred Strains
Microvilli
/ enzymology
Weaning
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
02 12 2019
02 12 2019
Historique:
received:
08
02
2019
accepted:
08
11
2019
entrez:
4
12
2019
pubmed:
4
12
2019
medline:
18
12
2020
Statut:
epublish
Résumé
The first thousand days of life are a critical time of development in humans during which the risk profile for diseases in later life can be modified. Nevertheless, long-term consequences of early environment on susceptibility to intestinal diseases have not yet been assessed. Using a mouse model of postnatal growth restriction (PNGR), we showed that early life nutrition influences intestinal maturation and gut health in later life. PNGR induced an alteration of the intestinal barrier in pups at weaning, resulting in increased intestinal permeability, and affected gut bacterial colonization. Specifically, pups with PNGR harbored a decreased bacterial diversity, higher Enterococcus spp., Staphylococcus spp., and Escherichia-Shigella spp., and lower Odoribacter spp. and several members of the Lachnospiraceae family. The lack of an efficient intestinal barrier in early life and the dysbiosis induced by PNGR were associated with a higher susceptibility to chronic colitis in adulthood.
Identifiants
pubmed: 31792267
doi: 10.1038/s41598-019-54308-6
pii: 10.1038/s41598-019-54308-6
pmc: PMC6889478
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
18111Références
Clin Exp Immunol. 1998 Dec;114(3):385-91
pubmed: 9844047
Eur J Nutr. 2016 Aug;55(5):1875-90
pubmed: 26246200
Curr Gastroenterol Rep. 2007 Oct;9(5):385-92
pubmed: 17991339
Nature. 2013 Aug 8;500(7461):232-6
pubmed: 23842501
Nutrients. 2014 Jun 02;6(6):2165-78
pubmed: 24892374
Am J Physiol. 1995 Aug;269(2 Pt 1):C385-91
pubmed: 7653520
Inflamm Bowel Dis. 2013 Mar-Apr;19(4):712-9
pubmed: 23446335
Pediatr Res. 1981 Jul;15(7):991-5
pubmed: 6114473
Am J Pathol. 2012 Feb;180(2):626-35
pubmed: 22155109
Nat Methods. 2010 May;7(5):335-6
pubmed: 20383131
Gut. 2004 Apr;53(4):501-6
pubmed: 15016743
Cell. 2009 Oct 30;139(3):485-98
pubmed: 19836068
Immunology. 2004 Oct;113(2):153-62
pubmed: 15379975
Nucleic Acids Res. 2013 Jan 7;41(1):e1
pubmed: 22933715
J Nutr. 2013 Aug;143(8):1225-32
pubmed: 23761650
Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G165-72
pubmed: 16844678
PLoS One. 2014 May 29;9(5):e97532
pubmed: 24873968
Immunity. 2019 May 21;50(5):1276-1288.e5
pubmed: 30902637
Am J Physiol. 1991 Nov;261(5 Pt 1):G763-9
pubmed: 1683165
Mediators Inflamm. 2017;2017:9074601
pubmed: 28316376
Nutr Rev. 2017 Mar 1;75(3):175-187
pubmed: 28340001
Stand Genomic Sci. 2011 Apr 29;4(2):200-9
pubmed: 21677857
Cell. 2010 Mar 19;140(6):859-70
pubmed: 20303876
J Nutr. 2009 Sep;139(9):1619-25
pubmed: 19625695
Sci Rep. 2015 May 14;5:9577
pubmed: 25974250
Nat Rev Microbiol. 2013 Apr;11(4):227-38
pubmed: 23435359
ISME J. 2012 Aug;6(8):1621-4
pubmed: 22402401
Science. 2013 Aug 2;341(6145):569-73
pubmed: 23828891
J Nutr Biochem. 1999 May;10(5):299-305
pubmed: 15539303
J Intern Med. 2007 May;261(5):412-7
pubmed: 17444880
Genome Res. 2011 Mar;21(3):494-504
pubmed: 21212162
PLoS One. 2014 Feb 20;9(2):e88382
pubmed: 24586321
BMC Bioinformatics. 2006 Aug 07;7:371
pubmed: 16893466
Bioinformatics. 2010 Oct 1;26(19):2460-1
pubmed: 20709691
Gastroenterology. 2006 Apr;130(4):1169-80
pubmed: 16618411
J Allergy Clin Immunol. 2009 Jul;124(1):3-20; quiz 21-2
pubmed: 19560575
Nucleic Acids Res. 2007;35(21):7188-96
pubmed: 17947321
Pediatr Res. 2009 Jul;66(1):47-52
pubmed: 19287349
Physiol Rev. 2014 Oct;94(4):1027-76
pubmed: 25287859
Gut. 2000 Apr;46(4):493-9
pubmed: 10716678
Am J Clin Nutr. 1989 Aug;50(2):261-8
pubmed: 2502904
Cell Host Microbe. 2011 Oct 20;10(4):311-23
pubmed: 22018232
Nutr Rev. 2015 Jun;73(6):359-75
pubmed: 26011911
Science. 2011 May 20;332(6032):974-7
pubmed: 21512004
Science. 2012 Apr 27;336(6080):489-93
pubmed: 22442383
Gastroenterology. 2014 Nov;147(5):1055-63.e8
pubmed: 25046162
JPEN J Parenter Enteral Nutr. 1996 Nov-Dec;20(6):406-11
pubmed: 8950741
Appl Environ Microbiol. 2005 Dec;71(12):8228-35
pubmed: 16332807
Am J Physiol Gastrointest Liver Physiol. 2010 Dec;299(6):G1376-85
pubmed: 20864654
Am J Physiol. 1991 Jun;260(6 Pt 2):R1104-13
pubmed: 2058738
Nucleic Acids Res. 2009 Jan;37(Database issue):D141-5
pubmed: 19004872
Nat Rev Immunol. 2010 Feb;10(2):131-44
pubmed: 20098461
J Nutr. 2010 Mar;140(3):461-8
pubmed: 20089775
Gastroenterology. 1999 Mar;116(3):702-31
pubmed: 10029630
J Pediatr Gastroenterol Nutr. 2001 Nov;33(5):592-601
pubmed: 11740235