Behavioural responses to a photovoltaic subretinal prosthesis implanted in non-human primates.

Animals Disease Models, Animal Eye Movement Measurements Macaca fascicularis Macular Degeneration / physiopathology Male Photic Stimulation Retinal Ganglion Cells / physiology Saccades Vision, Ocular / physiology Visual Perception Visual Prosthesis

Journal

Nature biomedical engineering

ISSN: 2157-846X

Titre abrégé: Nat Biomed Eng

Pays: England

ID NLM: 101696896

Informations de publication

Date de publication:
02 2020

Historique:

received: 18 04 2018

accepted: 23 10 2019

pubmed: 4 12 2019

medline: 6 5 2020

entrez: 4 12 2019

Statut: ppublish

Résumé

Retinal dystrophies and age-related macular degeneration related to photoreceptor degeneration can cause blindness. In blind patients, although the electrical activation of the residual retinal circuit can provide useful artificial visual perception, the resolutions of current retinal prostheses have been limited either by large electrodes or small numbers of pixels. Here we report the evaluation, in three awake non-human primates, of a previously reported near-infrared-light-sensitive photovoltaic subretinal prosthesis. We show that multipixel stimulation of the prosthesis within radiation safety limits enabled eye tracking in the animals, that they responded to stimulations directed at the implant with repeated saccades and that the implant-induced responses were present two years after device implantation. Our findings pave the way for the clinical evaluation of the prosthesis in patients affected by dry atrophic age-related macular degeneration.

Identifiants

DOI: 10.1038/s41551-019-0484-2 PMID: 31792423

pubmed: 31792423

doi: 10.1038/s41551-019-0484-2

pii: 10.1038/s41551-019-0484-2

doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

172-180

Commentaires et corrections

Type : CommentIn

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