The effect of a low-dose naloxone infusion on the incidence of respiratory depression after intrathecal morphine administration for major open hepatobiliary surgery: a randomised controlled trial.
Adult
Aged
Analgesics, Opioid
/ administration & dosage
Biliary Tract Surgical Procedures
Digestive System Diseases
/ surgery
Female
Humans
Incidence
Infusions, Intravenous
Injections, Spinal
Liver
/ surgery
Male
Middle Aged
Morphine
/ administration & dosage
Naloxone
/ administration & dosage
Narcotic Antagonists
/ administration & dosage
Pain, Postoperative
/ drug therapy
Respiratory Insufficiency
/ chemically induced
Young Adult
intrathecal morphine
naloxone
opioid reversal
respiratory depression
Journal
Anaesthesia
ISSN: 1365-2044
Titre abrégé: Anaesthesia
Pays: England
ID NLM: 0370524
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
accepted:
24
10
2019
pubmed:
4
12
2019
medline:
25
6
2020
entrez:
4
12
2019
Statut:
ppublish
Résumé
Intrathecal morphine is an analgesic option for major hepatopancreaticobiliary procedures but is associated with a risk of respiratory depression. We hypothesised that a postoperative low-dose naloxone infusion would reduce the incidence of respiratory depression without an increase in pain scores. Patients scheduled for major open hepatopancreaticobiliary surgery and who were receiving 10 μg.kg
Substances chimiques
Analgesics, Opioid
0
Narcotic Antagonists
0
Naloxone
36B82AMQ7N
Morphine
76I7G6D29C
Banques de données
EudraCT
['2015‐003504‐22']
ClinicalTrials.gov
['NCT02885948']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
747-755Informations de copyright
© 2019 Association of Anaesthetists.
Références
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