Endothelial-platelet interactions in influenza-induced pneumonia: A potential therapeutic target.
endothelial cell
influenza
interaction
laboratory animals
lung injury
platelet
pneumonia
therapy
Journal
Anatomia, histologia, embryologia
ISSN: 1439-0264
Titre abrégé: Anat Histol Embryol
Pays: Germany
ID NLM: 7704218
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
24
07
2019
revised:
07
10
2019
accepted:
08
11
2019
pubmed:
4
12
2019
medline:
3
9
2021
entrez:
4
12
2019
Statut:
ppublish
Résumé
Every year, influenza viruses spread around the world, infecting the respiratory systems of countless humans and animals, causing illness and even death. Severe influenza infection is associated with pulmonary epithelial damage and endothelial dysfunction leading to acute lung injury (ALI). There is evidence that an aggressive cytokine storm and cell damage in lung capillaries as well as endothelial/platelet interactions contribute to vascular leakage, pro-thrombotic milieu and infiltration of immune effector cells. To date, treatments for ALI caused by influenza are limited to antiviral drugs, active ventilation or further symptomatic treatments. In this review, we summarize the mechanisms of influenza-mediated pathogenesis, permissive animal models and histopathological changes of lung tissue in both mice and men and compare it with histological and electron microscopic data from our own group. We highlight the molecular and cellular interactions between pulmonary endothelium and platelets in homeostasis and influenza-induced pathogenesis. Finally, we discuss novel therapeutic targets on platelets/endothelial interaction to reduce or resolve ALI.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
606-619Subventions
Organisme : German Research Foundation (DFG)
Informations de copyright
© 2019 The Authors. Anatomia, Histologia, Embryologia published by Wiley-VCH GmbH.
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