Analysis of stochastic fluctuations in responsiveness is a critical step toward personalized anesthesia.
anesthesia
individual differences
mouse
neuroscience
personalized medicine
physics of living systems
state transitions
stochastic fluctuations
zebrafish
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
03 12 2019
03 12 2019
Historique:
received:
12
07
2019
accepted:
29
10
2019
entrez:
4
12
2019
pubmed:
4
12
2019
medline:
8
5
2020
Statut:
epublish
Résumé
Traditionally, drug dosing is based on a concentration-response relationship estimated in a population. Yet, in specific individuals, decisions based on the population-level effects frequently result in over or under-dosing. Here, we interrogate the relationship between population-based and individual-based responses to anesthetics in mice and zebrafish. The anesthetic state was assessed by quantifying responses to simple stimuli. Individual responses dynamically fluctuated at a fixed drug concentration. These fluctuations exhibited resistance to state transitions. Drug sensitivity varied dramatically across individuals in both species. The amount of noise driving transitions between states, in contrast, was highly conserved in vertebrates separated by 400 million years of evolution. Individual differences in anesthetic sensitivity and stochastic fluctuations in responsiveness complicate the ability to appropriately dose anesthetics to each individual. Identifying the biological substrate of noise, however, may spur novel therapies, assure consistent drug responses, and encourage the shift from population-based to personalized medicine.
Identifiants
pubmed: 31793434
doi: 10.7554/eLife.50143
pii: 50143
pmc: PMC6890463
doi:
pii:
Substances chimiques
Anesthetics
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : R01 GM088156
Pays : United States
Organisme : NIH HHS
ID : R01 GM107117
Pays : United States
Organisme : NIH HHS
ID : R01 GM124023
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM088156
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM112596
Pays : United States
Organisme : NIH HHS
ID : K08 GM123317
Pays : United States
Organisme : NIH HHS
ID : T32 GM112596
Pays : United States
Organisme : NIGMS NIH HHS
ID : K08 GM123317
Pays : United States
Informations de copyright
© 2019, McKinstry-Wu et al.
Déclaration de conflit d'intérêts
AM, AW, BH, VB, MS, JB, MP, MK, AP No competing interests declared
Références
J Physiol. 1952 Apr;116(4):449-72
pubmed: 14946713
Seizure. 2011 Jun;20(5):359-68
pubmed: 21292505
Nat Protoc. 2009;4(10):1422-32
pubmed: 19745824
Nature. 2005 Oct 27;437(7063):1257-63
pubmed: 16251950
Sci Rep. 2019 Mar 20;9(1):4927
pubmed: 30894626
J Neurosci. 2004 Jul 14;24(28):6291-300
pubmed: 15254084
Anesth Analg. 2009 Feb;108(2):491-5
pubmed: 19151277
Anesthesiology. 2018 Sep;129(3):459-476
pubmed: 29894316
Science. 2008 Dec 5;322(5907):1511-6
pubmed: 19023046
J Physiol. 1996 Apr 1;492 ( Pt 1):129-42
pubmed: 8730589
Anesthesiology. 2017 Feb;126(2):214-222
pubmed: 27984262
BMC Anesthesiol. 2006 Nov 10;6:13
pubmed: 17096844
Annu Rev Physiol. 1984;46:455-72
pubmed: 6143532
Clin Pharmacokinet. 2003;42(7):647-63
pubmed: 12844326
J Neurosci. 2006 Jan 25;26(4):1314-28
pubmed: 16436619
J Neurosci. 2014 Feb 26;34(9):3142-60
pubmed: 24573274
J Comput Neurosci. 1998 Dec;5(4):383-405
pubmed: 9877021
J Neurosci. 2015 Jul 29;35(30):10866-77
pubmed: 26224868
Br J Pharmacol. 1998 Nov;125(5):924-47
pubmed: 9846630
PLoS Genet. 2013;9(9):e1003605
pubmed: 24039590
J Neurosci Methods. 2014 Apr 30;227:65-74
pubmed: 24530701
Eur J Clin Pharmacol. 1975 Oct 10;9(1):1-8
pubmed: 786685
J Pharmacokinet Biopharm. 1984 Apr;12(2):223-40
pubmed: 6491902
PLoS One. 2008 Apr 16;3(4):e2004
pubmed: 18414674
Br J Pharmacol. 2006 Jan;147 Suppl 1:S72-81
pubmed: 16402123
Br J Anaesth. 2018 Jul;121(1):86-94
pubmed: 29935600
J Neurophysiol. 2007 Sep;98(3):1125-39
pubmed: 17615138
Science. 2006 Oct 6;314(5796):85-90
pubmed: 17023650
Science. 2008 Apr 4;320(5872):65-8
pubmed: 18388284
Anesthesiology. 2019 Jun;130(6):870-884
pubmed: 30946055
Nat Neurosci. 2002 Oct;5(10):979-84
pubmed: 12195434
Proc Natl Acad Sci U S A. 1982 Dec;79(24):7749-53
pubmed: 6296849
Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9283-8
pubmed: 24927558
Br J Anaesth. 2018 Mar;120(3):525-536
pubmed: 29452809
J R Soc Interface. 2016 Jan;13(114):20151027
pubmed: 26819336
N Engl J Med. 2011 Aug 18;365(7):591-600
pubmed: 21848460
N Engl J Med. 2008 Mar 13;358(11):1097-108
pubmed: 18337600
Nat Rev Neurosci. 2008 May;9(5):370-86
pubmed: 18425091
Science. 2004 Jun 18;304(5678):1811-4
pubmed: 15166317
Anaesthesia. 2013 May;68(5):502-11
pubmed: 23521699
Phys Rev Lett. 2009 Jul 31;103(5):058101
pubmed: 19792536
J Neurosurg Anesthesiol. 2013 Jan;25(1):33-42
pubmed: 23027226
Anesth Analg. 2014 Apr;118(4):809-17
pubmed: 24413548
J Anesth. 2011 Feb;25(1):65-71
pubmed: 21153424
Dev Dyn. 1995 Jul;203(3):253-310
pubmed: 8589427
Anesth Analg. 2002 Sep;95(3):609-14, table of contents
pubmed: 12198046
Anesthesiology. 1979 Jun;50(6):505-9
pubmed: 572191
Gen Hosp Psychiatry. 2001 Jul-Aug;23(4):198-204
pubmed: 11543846
J Physiol. 1982 Oct;331:311-31
pubmed: 6296368
Proc Natl Acad Sci U S A. 1997 Feb 4;94(3):814-9
pubmed: 9023339
Genome Res. 2015 Aug;25(8):1125-34
pubmed: 26129709
J Physiol. 2007 Jun 1;581(Pt 2):649-63
pubmed: 17379635
PLoS One. 2014 Sep 29;9(9):e106291
pubmed: 25264892
J Neurosci. 2010 Aug 11;30(32):10734-43
pubmed: 20702704
Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3859-64
pubmed: 24567395
J Neurosci. 2007 May 2;27(18):4984-94
pubmed: 17475807
Science. 2002 Aug 16;297(5584):1183-6
pubmed: 12183631
Neuropeptides. 2009 Jun;43(3):179-85
pubmed: 19464733
Front Neural Circuits. 2014 Mar 25;8:20
pubmed: 24723852
J Physiol. 1954 Jun 28;124(3):586-604
pubmed: 13175201
J Physiol. 1975 Oct;251(2):465-82
pubmed: 171380
Nature. 1983 Dec 1-7;306(5942):436-41
pubmed: 6316158
Science. 1990 Oct 26;250(4980):533-8
pubmed: 2122519
Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1309-14
pubmed: 18195361
Br J Anaesth. 2017 Oct 1;119(4):664-673
pubmed: 29121278
J Neurosci. 1999 Apr 15;19(8):2960-73
pubmed: 10191314
Anesth Analg. 2016 Jan;122(1):234-42
pubmed: 26418126
Anesthesiology. 1997 Mar;86(3):613-9
pubmed: 9066327
Nat Chem Biol. 2006 Sep;2(9):458-66
pubmed: 16921358
Neuron. 1989 Nov;3(5):589-96
pubmed: 2484342
Anesthesiology. 1998 Mar;88(3):642-50
pubmed: 9523807
PLoS One. 2010 Jul 30;5(7):e11903
pubmed: 20689589
Curr Biol. 2012 Nov 6;22(21):2008-16
pubmed: 23103189
Anesthesiology. 2017 Oct;127(4):645-657
pubmed: 28665814
Anesth Analg. 2000 Sep;91(3):720-6
pubmed: 10960407
Nature. 2006 Jun 15;441(7095):840-6
pubmed: 16699522
Nat Rev Neurosci. 2005 Jan;6(1):57-69
pubmed: 15611727
Anesthesiology. 2011 Dec;115(6):1209-18
pubmed: 22037642
Neuroscience. 2004;126(2):467-84
pubmed: 15207365
PLoS Biol. 2007 Oct 16;5(10):e277
pubmed: 17941721
J Clin Neurophysiol. 2001 May;18(3):275-82
pubmed: 11528299
Methods Enzymol. 2018;602:211-228
pubmed: 29588030
Anesthesiology. 2019 Jun;130(6):885-897
pubmed: 30946057
Nat Neurosci. 2015 Apr;18(4):553-561
pubmed: 25706476