Shotgun lipidomics-based characterization of the landscape of lipid metabolism in colorectal cancer.
Cancer
Colon
Lipid metabolism
Mass spectrometry
Shotgun lipidomics
Journal
Biochimica et biophysica acta. Molecular and cell biology of lipids
ISSN: 1879-2618
Titre abrégé: Biochim Biophys Acta Mol Cell Biol Lipids
Pays: Netherlands
ID NLM: 101731727
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
31
07
2019
revised:
24
10
2019
accepted:
20
11
2019
pubmed:
4
12
2019
medline:
16
7
2020
entrez:
4
12
2019
Statut:
ppublish
Résumé
Solid tumors are characterized by global metabolic alterations which contribute to their growth and progression. Altered gene expression profiles and plasma lipid composition suggested a role for metabolic reprogramming in colorectal cancer (CRC) development. However, a conclusive picture of CRC-associated lipidome alterations in the tumor tissue has not emerged. Here, we determined molar abundances of 342 species from 20 lipid classes in matched biopsies of CRC and adjacent normal mucosa. We demonstrate that in contrast to previous reports, CRC shows a largely preserved lipidome composition that resembles that of normal colonic mucosa. Important exceptions include increased levels of lyso-phosphatidylinositols in CRC and reduced abundance of ether phospholipids in advanced stages of CRC. As such, our observations challenge the concept of widespread alterations in lipid metabolism in CRC and rather suggest changes in the cellular lipid profile that are limited to selected lipids involved in signaling and the scavenging of reactive oxygen species.
Identifiants
pubmed: 31794862
pii: S1388-1981(19)30230-6
doi: 10.1016/j.bbalip.2019.158579
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
158579Informations de copyright
Copyright © 2019. Published by Elsevier B.V.