The effect of alcohol dose on the development of hypertension in Asian and Western men: systematic review and meta-analysis.
Alcohol
Dose-response relationship
Ethnic groups
Hypertension
Meta-analysis
Journal
The Korean journal of internal medicine
ISSN: 2005-6648
Titre abrégé: Korean J Intern Med
Pays: Korea (South)
ID NLM: 8712418
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
10
01
2019
accepted:
08
02
2019
pubmed:
5
12
2019
medline:
25
6
2021
entrez:
5
12
2019
Statut:
ppublish
Résumé
There are inconsistencies in the effects of low to moderate dose alcohol consumption on the development of hypertension in adult men. We hypothesized that a region-specific effect might participate in this heterogeneity. We conducted a systematic review and meta-analysis to evaluate the effect of alcohol dose on hypertension incidence using contemporary data through December 2017. Subjects were categorized according to their level of alcohol consumption as non-drinkers (reference) and low- (0.01 to 20.0 g/day), moderate- (20.1 to 40.0 g/day), moderate- to high- (40.1 to 60.0 g/day), and high-dose (> 60.0 g/day) drinkers. We defined hypertension as a blood pressure ≥ 140/90 mmHg and/or the use of anti-hypertensive drugs. In total, 11 articles (seven Asian and four Western) were selected for our analysis. Among Asian men, a significantly elevated risk was observed even in the low alcohol dose group in comparison with the group with no alcohol consumption, and the risk increased in a dose-dependent manner (pooled relative risks [95% confidence intervals (CI)]: 1.25 [1.13 to 1.38], 1.48 [1.27 to 1.72], 1.75 [1.43 to 2.15], and 1.78 [1.51 to 2.09]). Among Western men, a similar dose-response relationship was noted in general (p for subgroup difference > 0.1), but a significantly elevated risk was evident only in the high-dose group (pooled relative risks [95% CI]: 1.22 [0.85 to 1.74], 1.57 [0.90 to 2.75], 1.47 [0.44 to 4.91], and 1.49 [1.02 to 2.18]). Even low doses of alcohol can lead to the development of hypertension, particularly in Asian men. Our findings could serve as additional evidence for developing an appropriate preventive strategy in each region.
Sections du résumé
BACKGROUND/AIMS
There are inconsistencies in the effects of low to moderate dose alcohol consumption on the development of hypertension in adult men. We hypothesized that a region-specific effect might participate in this heterogeneity.
METHODS
We conducted a systematic review and meta-analysis to evaluate the effect of alcohol dose on hypertension incidence using contemporary data through December 2017. Subjects were categorized according to their level of alcohol consumption as non-drinkers (reference) and low- (0.01 to 20.0 g/day), moderate- (20.1 to 40.0 g/day), moderate- to high- (40.1 to 60.0 g/day), and high-dose (> 60.0 g/day) drinkers. We defined hypertension as a blood pressure ≥ 140/90 mmHg and/or the use of anti-hypertensive drugs.
RESULTS
In total, 11 articles (seven Asian and four Western) were selected for our analysis. Among Asian men, a significantly elevated risk was observed even in the low alcohol dose group in comparison with the group with no alcohol consumption, and the risk increased in a dose-dependent manner (pooled relative risks [95% confidence intervals (CI)]: 1.25 [1.13 to 1.38], 1.48 [1.27 to 1.72], 1.75 [1.43 to 2.15], and 1.78 [1.51 to 2.09]). Among Western men, a similar dose-response relationship was noted in general (p for subgroup difference > 0.1), but a significantly elevated risk was evident only in the high-dose group (pooled relative risks [95% CI]: 1.22 [0.85 to 1.74], 1.57 [0.90 to 2.75], 1.47 [0.44 to 4.91], and 1.49 [1.02 to 2.18]).
CONCLUSION
Even low doses of alcohol can lead to the development of hypertension, particularly in Asian men. Our findings could serve as additional evidence for developing an appropriate preventive strategy in each region.
Identifiants
pubmed: 31795024
pii: kjim.2019.016
doi: 10.3904/kjim.2019.016
pmc: PMC7373951
doi:
Substances chimiques
Antihypertensive Agents
0
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
906-916Références
Hypertension. 1991 Dec;18(6):819-26
pubmed: 1683858
Alcohol Clin Exp Res. 2002 Jul;26(7):988-94
pubmed: 12170108
N Engl J Med. 1977 May 26;296(21):1194-200
pubmed: 854058
PLoS One. 2016 Sep 19;11(9):e0163044
pubmed: 27643787
Hypertension. 2004 Dec;44(6):813-9
pubmed: 15477381
Circulation. 2018 Oct 23;138(17):e426-e483
pubmed: 30354655
Am J Epidemiol. 1997 Nov 1;146(9):727-33
pubmed: 9366620
J Hum Hypertens. 2004 Jul;18(7):487-94
pubmed: 14961044
Am J Epidemiol. 2010 Mar 1;171(5):532-9
pubmed: 20118194
Hypertension. 2001 May;37(5):1242-50
pubmed: 11358935
Alcohol Clin Exp Res. 2002 Jul;26(7):1010-6
pubmed: 12170111
Hypertension. 2014 Jan;63(1):41-7
pubmed: 24126168
J Clin Hypertens (Greenwich). 2012 Nov;14(11):792-8
pubmed: 23126352
J Hypertens. 2017 Feb;35(2):250-258
pubmed: 27846042
Control Clin Trials. 1986 Sep;7(3):177-88
pubmed: 3802833
Hypertension. 2008 Apr;51(4):1080-7
pubmed: 18259032
Addiction. 2009 Dec;104(12):1981-90
pubmed: 19804464
Hum Genet. 1989 Apr;82(1):14-6
pubmed: 2714775
Alcohol Clin Exp Res. 1996 Dec;20(9):1569-76
pubmed: 8986205
J Hypertens. 1998 Jun;16(6):753-9
pubmed: 9663915
Lancet. 2009 Jun 27;373(9682):2223-33
pubmed: 19560604
BMC Med Res Methodol. 2014 Apr 01;14:45
pubmed: 24690082
J Am Heart Assoc. 2018 Jun 27;7(13):
pubmed: 29950485
Biometrics. 2000 Jun;56(2):455-63
pubmed: 10877304
Lancet Public Health. 2017 Feb;2(2):e108-e120
pubmed: 29253389
Reprod Sci. 2008 Jan;15(1):9-25
pubmed: 18212350
Herz. 2018 Jun;43(4):352-358
pubmed: 28534177
N Engl J Med. 1990 Jan 11;322(2):95-9
pubmed: 2248624
J Hypertens. 2001 May;19(5):851-5
pubmed: 11393666
Am J Hypertens. 2014 Jun;27(6):801-10
pubmed: 24436325
J Hypertens. 2013 Dec;31(12):2342-7
pubmed: 24029874
Am J Cardiol. 1990 Mar 1;65(9):633-7
pubmed: 2309634
Lancet. 2016 Oct 8;388(10053):1659-1724
pubmed: 27733284
Am J Hypertens. 2000 May;13(5 Pt 1):482-7
pubmed: 10826398
BMJ. 1997 Sep 13;315(7109):629-34
pubmed: 9310563
J Hypertens. 2018 Dec;36(12):2284-2309
pubmed: 30379783
J Stud Alcohol. 2004 Mar;65(2):184-90
pubmed: 15151348
Pulse (Basel). 2015 May;3(1):35-47
pubmed: 26587456
World J Cardiol. 2014 May 26;6(5):245-52
pubmed: 24891935
Science. 1972 Jan 28;175(4020):449-50
pubmed: 5007912
J Am Soc Hypertens. 2008 Sep-Oct;2(5):307-17
pubmed: 20409912
BMJ. 2003 Sep 6;327(7414):557-60
pubmed: 12958120