Deubiquitinating Enzymes: A Critical Regulator of Mitosis.
cancer
deubiquitination
mitosis
ubiquitination
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
28 Nov 2019
28 Nov 2019
Historique:
received:
06
11
2019
revised:
25
11
2019
accepted:
25
11
2019
entrez:
5
12
2019
pubmed:
5
12
2019
medline:
15
4
2020
Statut:
epublish
Résumé
Mitosis is a complex and dynamic process that is tightly regulated by a large number of mitotic proteins. Dysregulation of these proteins can generate daughter cells that exhibit genomic instability and aneuploidy, and such cells can transform into tumorigenic cells. Thus, it is important for faithful mitotic progression to regulate mitotic proteins at specific locations in the cells at a given time in each phase of mitosis. Ubiquitin-dependent modifications play critical roles in this process by regulating the degradation, translocation, or signal transduction of mitotic proteins. Here, we review how ubiquitination and deubiquitination regulate the progression of mitosis. In addition, we summarize the substrates and roles of some deubiquitinating enzymes (DUBs) crucial for mitosis and describe how they contribute error correction during mitosis and control the transition between the mitotic phases.
Identifiants
pubmed: 31795161
pii: ijms20235997
doi: 10.3390/ijms20235997
pmc: PMC6929034
pii:
doi:
Substances chimiques
Ubiquitin-Protein Ligases
EC 2.3.2.27
Deubiquitinating Enzymes
EC 3.4.19.12
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Research Foundation of Korea
ID : 2019R1A2C2004052 and 2017R1A2B3007224
Organisme : R&D Convergence Program of National Research Council of Science & Technology of Korea
ID : CAP-16-03-KRIBB
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