IFNα and IFNγ Impede Marek's Disease Progression.
Marek’s disease virus
antitumor immune response
antiviral host defense
chicken cytokines
innate immunity
recombinant interferons
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
28 11 2019
28 11 2019
Historique:
received:
01
11
2019
revised:
25
11
2019
accepted:
27
11
2019
entrez:
5
12
2019
pubmed:
5
12
2019
medline:
6
10
2020
Statut:
epublish
Résumé
Marek's disease virus (MDV) is an alphaherpesvirus that causes Marek's disease, a malignant lymphoproliferative disease of domestic chickens. While MDV vaccines protect animals from clinical disease, they do not provide sterilizing immunity and allow field strains to circulate and evolve in vaccinated flocks. Therefore, there is a need for improved vaccines and for a better understanding of innate and adaptive immune responses against MDV infections. Interferons (IFNs) play important roles in the innate immune defenses against viruses and induce upregulation of a cellular antiviral state. In this report, we quantified the potent antiviral effect of IFNα and IFNγ against MDV infections in vitro. Moreover, we demonstrate that both cytokines can delay Marek's disease onset and progression in vivo. Additionally, blocking of endogenous IFNα using a specific monoclonal antibody, in turn, accelerated disease. In summary, our data reveal the effects of IFNα and IFNγ on MDV infection and improve our understanding of innate immune responses against this oncogenic virus.
Identifiants
pubmed: 31795203
pii: v11121103
doi: 10.3390/v11121103
pmc: PMC6950089
pii:
doi:
Substances chimiques
Antibodies, Monoclonal
0
Interferon-alpha
0
Marek Disease Vaccines
0
Interferon-gamma
82115-62-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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