Matrix Metalloproteinase Triple-Helical Peptide Inhibitors: Potential Cross-Reactivity with Caspase-11.
caspase
matrix metalloproteinase
phosphinate
protease inhibitor
sepsis
triple-helical peptide inhibitor
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
28 Nov 2019
28 Nov 2019
Historique:
received:
30
10
2019
revised:
25
11
2019
accepted:
26
11
2019
entrez:
5
12
2019
pubmed:
5
12
2019
medline:
18
4
2020
Statut:
epublish
Résumé
Triple-helical peptide inhibitors (THPIs) of matrix metalloproteinases (MMPs) have recently been demonstrated to be effective in a variety of animal models of disease, coincidental with knockout studies. However, passenger mutations have been described in MMP knockout mice that impact the activity of other proteins, including caspase-11. Thus, it is possible that the results observed with THPIs may be based on inhibition of caspase-11, not MMPs. The present study evaluated whether THPIs were cross-reactive with caspase-11. Two different THPIs were tested, one that is known to inhibit MMP-1 and MMP-8 (GlyΨ{PO
Identifiants
pubmed: 31795279
pii: molecules24234355
doi: 10.3390/molecules24234355
pmc: PMC6930605
pii:
doi:
Substances chimiques
Caspase Inhibitors
0
Matrix Metalloproteinase Inhibitors
0
Caspases
EC 3.4.22.-
caspase 11, human
EC 3.4.22.-
Matrix Metalloproteinases
EC 3.4.24.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : CA098799
Pays : United States
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