Effect of industrial point-source air pollutants on fractional exhaled nitric oxide in healthy volunteers.
Air pollution
FeNO
Human
Industry
Lung inflammation
Journal
Environmental research
ISSN: 1096-0953
Titre abrégé: Environ Res
Pays: Netherlands
ID NLM: 0147621
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
25
02
2019
revised:
05
11
2019
accepted:
26
11
2019
pubmed:
5
12
2019
medline:
5
9
2020
entrez:
5
12
2019
Statut:
ppublish
Résumé
Few studies have examined the effects of industrial, fixed-site sources of air pollution on lung inflammation in nearby residents. We investigated the effects of short-term exposure to ambient air near a steel plant on the fractional exhaled concentration of nitric oxide (FeNO), a measure of airway inflammation, in healthy volunteers. A cross-over study design was used. Fifty-nine non-smoking participants (mean age 24 years) were randomly assigned to each of two 5-day exposure scenarios: breathing ambient air adjacent to a steel plant or 5 km away at a college campus site. FeNO and on-site air pollutants were measured daily. Mixed effects linear regression models were used for data analysis, adjusting for sex, temperature, humidity and day of week. Compared with the college site, PM Exposure to ambient air near a steel plant was associated with increased airway inflammation as measured by exhaled nitric oxide.
Sections du résumé
BACKGROUND
Few studies have examined the effects of industrial, fixed-site sources of air pollution on lung inflammation in nearby residents. We investigated the effects of short-term exposure to ambient air near a steel plant on the fractional exhaled concentration of nitric oxide (FeNO), a measure of airway inflammation, in healthy volunteers.
METHODS
A cross-over study design was used. Fifty-nine non-smoking participants (mean age 24 years) were randomly assigned to each of two 5-day exposure scenarios: breathing ambient air adjacent to a steel plant or 5 km away at a college campus site. FeNO and on-site air pollutants were measured daily. Mixed effects linear regression models were used for data analysis, adjusting for sex, temperature, humidity and day of week.
RESULTS
Compared with the college site, PM
CONCLUSIONS
Exposure to ambient air near a steel plant was associated with increased airway inflammation as measured by exhaled nitric oxide.
Identifiants
pubmed: 31796259
pii: S0013-9351(19)30762-5
doi: 10.1016/j.envres.2019.108965
pii:
doi:
Substances chimiques
Air Pollutants
0
Particulate Matter
0
Nitric Oxide
31C4KY9ESH
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108965Informations de copyright
Crown Copyright © 2019. Published by Elsevier Inc. All rights reserved.