An epigenetic predictor of death captures multi-modal measures of brain health.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
30
07
2019
accepted:
20
11
2019
revised:
14
11
2019
pubmed:
5
12
2019
medline:
28
1
2022
entrez:
5
12
2019
Statut:
ppublish
Résumé
Individuals of the same chronological age exhibit disparate rates of biological ageing. Consequently, a number of methodologies have been proposed to determine biological age and primarily exploit variation at the level of DNA methylation (DNAm). A novel epigenetic clock, termed 'DNAm GrimAge' has outperformed its predecessors in predicting the risk of mortality as well as many age-related morbidities. However, the association between DNAm GrimAge and cognitive or neuroimaging phenotypes remains unknown. We explore these associations in the Lothian Birth Cohort 1936 (n = 709, mean age 73 years). Higher DNAm GrimAge was strongly associated with all-cause mortality over the eighth decade (Hazard Ratio per standard deviation increase in GrimAge: 1.81, P < 2.0 × 10
Identifiants
pubmed: 31796892
doi: 10.1038/s41380-019-0616-9
pii: 10.1038/s41380-019-0616-9
pmc: PMC8550950
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3806-3816Subventions
Organisme : NIA NIH HHS
ID : U01 AG060908
Pays : United States
Organisme : Medical Research Council
ID : MR/R024065/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R01 AG054628
Pays : United States
Organisme : Medical Research Council
ID : MR/M013111/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1001245
Pays : United Kingdom
Organisme : Wellcome Trust (Wellcome)
ID : 108890/Z/15/Z
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0701120
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/F019394/1
Pays : United Kingdom
Informations de copyright
© 2019. The Author(s).
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