Replicability of structural brain alterations associated with general psychopathology: evidence from a population-representative birth cohort.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
02
04
2019
accepted:
22
11
2019
revised:
16
11
2019
pubmed:
5
12
2019
medline:
28
1
2022
entrez:
5
12
2019
Statut:
ppublish
Résumé
Transdiagnostic research has identified a general psychopathology factor-often called the 'p' factor-that accounts for shared variation across internalizing, externalizing, and thought disorders in diverse samples. It has been argued that the p factor may reflect dysfunctional thinking present in serious mental illness. In support of this, we previously used a theory-free, data-driven multimodal neuroimaging approach to find that higher p factor scores are associated with structural alterations within a cerebello-thalamo-cortical circuit (CTCC) and visual association cortex, both of which are important for monitoring and coordinating information processing in the service of executive control. Here we attempt to replicate these associations by conducting region-of-interest analyses using data from 875 members of the Dunedin Longitudinal Study, a five-decade study of a population-representative birth cohort, collected when they were 45 years old. We further sought to replicate a more recent report that p factor scores can be predicted by patterns of distributed cerebellar morphology as estimated through independent component analysis. We successfully replicated associations between higher p factor scores and both reduced gray matter volume of the visual association cortex and fractional anisotropy of pontine white matter pathways within the CTCC. In contrast, we failed to replicate prior associations between cerebellar structure and p factor scores. Collectively, our findings encourage further focus on the CTCC and visual association cortex as core neural substrates and potential biomarkers of general psychopathology.
Identifiants
pubmed: 31796893
doi: 10.1038/s41380-019-0621-z
pii: 10.1038/s41380-019-0621-z
pmc: PMC7266702
mid: EMS85027
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
3839-3846Subventions
Organisme : NIA NIH HHS
ID : R01 AG049789
Pays : United States
Organisme : Medical Research Council
ID : MR/P005918/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R01 AG032282
Pays : United States
Informations de copyright
© 2019. The Author(s).
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