Urinary metabolites identified using metabolomic analysis as potential biomarkers of nocturia in elderly men.
Mass spectrometry
Men
Metabolomic analysis
Nocturia
Urine biomarker
Journal
World journal of urology
ISSN: 1433-8726
Titre abrégé: World J Urol
Pays: Germany
ID NLM: 8307716
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
19
07
2019
accepted:
25
11
2019
pubmed:
5
12
2019
medline:
27
5
2021
entrez:
5
12
2019
Statut:
ppublish
Résumé
To investigate the association between nocturia and urinary metabolites in elderly men using metabolomic analysis. We recruited 66 men aged 65-80 years. The 3-day frequency volume chart (FCV), International Prostate Symptom Score (IPSS), and quality of life score were used to assess micturition behavior. Participants with the total IPSS > 0 and ≥ 1.5 micturition on an average for three nights were included in the nocturia group. Participants with the total IPSS < 8 and < 1.5 micturition at night were included in the control group. We conducted a comprehensive metabolomic analysis of urine samples. Metabolites were compared between the groups using an unpaired t test. A multivariable logistic regression analysis was used to determine the relationship between nocturia and these metabolites. The nocturia and control groups consisted of 45 and 21 men, respectively. There were no differences in the background factors between the groups except for receiving anticholinergic drug and having life style-related diseases. The FVC revealed that nocturnal urine volume, 24 h micturition frequency, and nocturnal micturition frequency were significantly higher in the nocturia group than in the control group. The metabolomic analysis revealed 16 metabolites, which were differentially expressed between the groups. The multivariate analysis showed that increased serotonin level and decreased 3-hydroxypropionic acid and 3-indoleacetonitrile levels were associated with nocturia. These findings suggest that abnormal urinary metabolites including serotonin, 3-hydroxypropionic acid, and 3-indoleacetonitrile are involved in the pathogenesis of nocturia in elderly men.
Identifiants
pubmed: 31797073
doi: 10.1007/s00345-019-03042-9
pii: 10.1007/s00345-019-03042-9
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
2563-2569Subventions
Organisme : Astellas Pharma
ID : a3
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