Association of non-exercise physical activity in mid- and late-life with cognitive trajectories and the impact of APOE ε4 genotype status: the Mayo Clinic Study of Aging.
APOE ε4
Cognitive trajectories
Non-exercise physical activity
Population-based study
Journal
European journal of ageing
ISSN: 1613-9372
Titre abrégé: Eur J Ageing
Pays: Germany
ID NLM: 101233661
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
entrez:
5
12
2019
pubmed:
5
12
2019
medline:
5
12
2019
Statut:
epublish
Résumé
In this study derived from the population-based Mayo Clinic Study of Aging, we investigated whether non-exercise physical activity (PA) was associated with global and domain-specific cognitive trajectories (memory, language, visuospatial skills, attention) and whether the association differed by apolipoprotein E (APOE) ε4 genotype status. We included 2061 community-dwelling individuals aged ≥ 70 years (50.5% males, 26.7% APOE ε4 carriers) who were cognitively unimpaired at baseline and on whom serial cognitive data and self-reported information on non-exercise PA were available. We specifically inquired about non-exercise PA carried out at two time points, i.e., midlife (between 50 and 65 years of age) and late-life (within 1 year prior to assessment) and three intensity levels, i.e., light (e.g., laundry), moderate (e.g., scrubbing floors) and heavy (e.g., hard manual labor). Linear mixed-effect models revealed that engaging in midlife PA of moderate or heavy intensity was associated with significantly less-pronounced decline of
Identifiants
pubmed: 31798373
doi: 10.1007/s10433-019-00513-1
pii: 513
pmc: PMC6857122
doi:
Types de publication
Journal Article
Langues
eng
Pagination
491-502Subventions
Organisme : NIA NIH HHS
ID : R01 AG034676
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG057708
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG006786
Pays : United States
Informations de copyright
© The Author(s) 2019.
Déclaration de conflit d'intérêts
Conflict of interestThe authors declare no conflict of interest related to this manuscript.
Références
J Lipid Res. 1990 Mar;31(3):545-8
pubmed: 2341813
Lancet Neurol. 2005 Nov;4(11):705-11
pubmed: 16239176
Alzheimers Dement. 2015 Apr;11(4):434-443.e6
pubmed: 24721528
Sports Med. 2018 Jun;48(6):1405-1436
pubmed: 29667159
Brain Plast. 2018 Dec 12;4(1):53-63
pubmed: 30564546
PLoS One. 2019 Jan 10;14(1):e0210036
pubmed: 30629631
J Gerontol. 1982 May;37(3):323-9
pubmed: 7069156
Vital Health Stat 10. 1986 Sep;(160):i-iv, 1-182
pubmed: 3811243
Psychosom Med. 2010 Apr;72(3):239-52
pubmed: 20223924
Front Neuroendocrinol. 2017 Jul;46:71-85
pubmed: 28442274
Med Sci Sports Exerc. 2001 May;33(5):772-7
pubmed: 11323547
Am J Epidemiol. 1985 Apr;121(4):570-9
pubmed: 4014146
J Clin Exp Neuropsychol. 1998 Apr;20(2):194-200
pubmed: 9777473
Med Sci Sports Exerc. 2017 Jan;49(1):47-53
pubmed: 27580146
J Am Geriatr Soc. 2010 Jul;58(7):1322-6
pubmed: 20609030
Neuroepidemiology. 2008;30(1):58-69
pubmed: 18259084
Science. 1993 Aug 13;261(5123):921-3
pubmed: 8346443
Exerc Sport Sci Rev. 2018 Oct;46(4):215-223
pubmed: 30001269
Ann Behav Med. 2018 Feb 5;52(2):175-185
pubmed: 29538632
J Chronic Dis. 1987;40(5):373-83
pubmed: 3558716
Arch Neurol. 2010 Jan;67(1):80-6
pubmed: 20065133
Arch Neurol. 1991 Jul;48(7):725-8
pubmed: 1859300
Psychol Sci. 2003 Mar;14(2):125-30
pubmed: 12661673
J Am Geriatr Soc. 2016 Dec;64(12):2479-2486
pubmed: 27801933
Perspect Psychol Sci. 2018 Mar;13(2):213-217
pubmed: 29592650
Alzheimers Dement (N Y). 2018 Jul 14;4:263-271
pubmed: 30090846
J Sci Med Sport. 2018 May;21(5):489-494
pubmed: 28919495
BMB Rep. 2018 Apr;51(4):167-173
pubmed: 29429452
J Am Geriatr Soc. 2013 Nov;61(11):1927-31
pubmed: 24219194
Annu Rev Med. 1996;47:387-400
pubmed: 8712790
Neurology. 2016 May 17;86(20):1897-903
pubmed: 27009261
J Epidemiol Community Health. 2018 Jun;72(6):477-483
pubmed: 29434025
Neurology. 1993 Aug;43(8):1467-72
pubmed: 8350998
Neurology. 1993 Nov;43(11):2412-4
pubmed: 8232972
Exp Gerontol. 2017 May;91:104-109
pubmed: 28263868
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2019 Jan;26(1):1-23
pubmed: 28868969
Sports Med. 2018 Jan;48(1):29-44
pubmed: 28940148
Arch Neurol. 2005 Nov;62(11):1750-4
pubmed: 16286550