An exploration of the gut and environmental resistome in a community in northern Vietnam in relation to antibiotic use.
Adolescent
Adult
Animals
Anti-Bacterial Agents
/ pharmacology
Bacteria
/ drug effects
Child
Child, Preschool
Drug Resistance, Multiple, Bacterial
/ genetics
Feces
/ microbiology
Female
Gastrointestinal Microbiome
/ drug effects
Genes, Bacterial
Humans
Infant
Infant, Newborn
Longitudinal Studies
Male
Metagenomics
Middle Aged
Pets
/ microbiology
Prospective Studies
Vietnam
Young Adult
Antibiotic use
Environmental resistome
Mcr-1
Mcr-3
Resistome
Vietnam
Journal
Antimicrobial resistance and infection control
ISSN: 2047-2994
Titre abrégé: Antimicrob Resist Infect Control
Pays: England
ID NLM: 101585411
Informations de publication
Date de publication:
2019
2019
Historique:
received:
29
05
2019
accepted:
04
11
2019
entrez:
5
12
2019
pubmed:
5
12
2019
medline:
18
7
2020
Statut:
epublish
Résumé
Antibiotic resistance is a major global public health threat. Antibiotic use can directly impact the antibiotic resistant genes (ARGs) profile of the human intestinal microbiome and consequently the environment through shedding. We determined the resistome of human feces, animal stools, human food and environmental (rain, well, and irrigative water) samples ( Nearly 40 % (39.5%, 120/304) of samples contained ESBL genes (most frequent were Our study indicated that ARGs were abundant in human and animal stools in a rural Vietnamese community, including ARGs targeting last resort antibiotics. The resistomes of animal and human stools were similar as opposed to the resistomes from water and food sources. No association between antibiotic use and ARG profiles was found in a setting of high background rates of AMR.
Sections du résumé
Background
Antibiotic resistance is a major global public health threat. Antibiotic use can directly impact the antibiotic resistant genes (ARGs) profile of the human intestinal microbiome and consequently the environment through shedding.
Methods
We determined the resistome of human feces, animal stools, human food and environmental (rain, well, and irrigative water) samples (
Results
Nearly 40 % (39.5%, 120/304) of samples contained ESBL genes (most frequent were
Conclusions
Our study indicated that ARGs were abundant in human and animal stools in a rural Vietnamese community, including ARGs targeting last resort antibiotics. The resistomes of animal and human stools were similar as opposed to the resistomes from water and food sources. No association between antibiotic use and ARG profiles was found in a setting of high background rates of AMR.
Identifiants
pubmed: 31798840
doi: 10.1186/s13756-019-0645-9
pii: 645
pmc: PMC6883630
doi:
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
194Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Informations de copyright
© The Author(s). 2019.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare that they have no competing interests.
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