Hydrogels Based on Poly(aspartic acid): Synthesis and Applications.
crosslinking
hydrogels
interpenetrating polymer networks (IPNs)
nanoparticles
poly(aspartic acid)
poly(succinimide)
Journal
Frontiers in chemistry
ISSN: 2296-2646
Titre abrégé: Front Chem
Pays: Switzerland
ID NLM: 101627988
Informations de publication
Date de publication:
2019
2019
Historique:
received:
21
08
2019
accepted:
22
10
2019
entrez:
5
12
2019
pubmed:
5
12
2019
medline:
5
12
2019
Statut:
epublish
Résumé
This review presents an overview on the recent progress in the synthesis, crosslinking, interpenetrating networks, and applications of poly(aspartic acid) (PASP)-based hydrogels. PASP is a synthetic acidic polypeptide that has drawn a great deal of attention in diverse applications due particularly to its biocompatibility and biodegradability. Facile modification of its precursor, poly(succinimide) (PSI), by primary amines has opened a wide window for the design of state-of-the-art hydrogels. Apart from pH-sensitivity, PASP hydrogels can be modified with suitable species in order to respond to the other desired stimuli such as temperature and reducing/oxidizing media as well. Strategies for fabrication of nanostructured PASP-based hydrogels in the form of particle and fiber are also discussed. Different cross-linking agents for PSI/PASP such as diamines, dopamine, cysteamine, and aminosilanes are also introduced. Finally, applications of PASP-based hydrogels in diverse areas particularly in biomedical are reviewed.
Identifiants
pubmed: 31799235
doi: 10.3389/fchem.2019.00755
pmc: PMC6861526
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
755Informations de copyright
Copyright © 2019 Adelnia, Blakey, Little and Ta.
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