Light-driven activation of mitochondrial proton-motive force improves motor behaviors in a
Animals
Biomarkers
Disease Models, Animal
Disease Susceptibility
Dopaminergic Neurons
/ metabolism
Drosophila
Light
Mitochondria
/ metabolism
Mitochondrial Diseases
/ etiology
Models, Biological
Motor Activity
Oxidative Stress
Parkinson Disease
/ etiology
Protons
Reactive Oxygen Species
/ metabolism
alpha-Synuclein
/ metabolism
Cell death in the nervous system
Energy metabolism
Gene expression
Optogenetics
Parkinson's disease
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
2019
2019
Historique:
received:
18
01
2019
accepted:
01
11
2019
entrez:
5
12
2019
pubmed:
5
12
2019
medline:
19
5
2020
Statut:
epublish
Résumé
Mitochondrial degeneration is considered one of the major causes of Parkinson's disease (PD). Improved mitochondrial functions are expected to be a promising therapeutic strategy for PD. In this study, we introduced a light-driven proton transporter, Delta-rhodopsin (dR), to
Identifiants
pubmed: 31799427
doi: 10.1038/s42003-019-0674-1
pii: 674
pmc: PMC6874642
doi:
Substances chimiques
Biomarkers
0
Protons
0
Reactive Oxygen Species
0
alpha-Synuclein
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
424Informations de copyright
© The Author(s) 2019.
Déclaration de conflit d'intérêts
Competing interestsThe authors have no conflicts of interest to declare.
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