Prevalence and Predictors of Frailty in Childhood Cancer Survivors and Siblings: A Report From the Childhood Cancer Survivor Study.
Journal
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
ISSN: 1527-7755
Titre abrégé: J Clin Oncol
Pays: United States
ID NLM: 8309333
Informations de publication
Date de publication:
20 01 2020
20 01 2020
Historique:
pubmed:
5
12
2019
medline:
1
7
2020
entrez:
5
12
2019
Statut:
ppublish
Résumé
To estimate the prevalence of frailty among childhood cancer survivors and to determine the direct and indirect effects of treatment exposures, lifestyle factors, and severe, disabling, and life-threatening chronic condition on frailty. Childhood cancer survivors (≥ 5 years since diagnosis), treated between 1970 and 1999 when < 21 years old (n = 10,899; mean age, 37.6 ± 9.4 years; 48% male, 86% white) and siblings were included (n = 2,097; mean age, 42.9 ± 9.4 years). Frailty was defined as ≥ 3 of the following: low lean mass, exhaustion, low energy expenditure, walking limitations, and weakness. Generalized linear models were used to evaluate direct and indirect associations between frailty and treatment exposures, sociodemographic characteristics, lifestyle factors, and chronic condition. The overall prevalence of frailty among survivors was 3 times higher compared with siblings (6.4%; 95% CI, 4.1% to 8.7%; Childhood cancer survivors reported a higher prevalence of frailty compared with siblings. Radiation and lung surgery exposures were associated with increased risk for frailty. Interventions to prevent, delay onset, or remediate chronic disease and/or promote healthy lifestyle are needed to decrease the prevalence of frailty and preserve function in this at-risk population.
Identifiants
pubmed: 31800343
doi: 10.1200/JCO.19.01226
pmc: PMC6968796
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
232-247Subventions
Organisme : NCI NIH HHS
ID : P30 CA021765
Pays : United States
Organisme : NCI NIH HHS
ID : U24 CA055727
Pays : United States
Références
Med Sci Sports Exerc. 2011 Aug;43(8):1575-81
pubmed: 21681120
Arch Intern Med. 2002 Nov 11;162(20):2333-41
pubmed: 12418947
Obesity (Silver Spring). 2015 Apr;23(4):847-55
pubmed: 25683024
Am J Epidemiol. 1999 Aug 1;150(3):245-54
pubmed: 10430228
J Clin Oncol. 2015 May 10;33(14):1592-600
pubmed: 25847925
Med Sci Sports Exerc. 2003 Mar;35(3):439-43
pubmed: 12618573
Acta Biomed. 2010;81 Suppl 1:37-45
pubmed: 20518190
J Sports Med Phys Fitness. 2017 Jun;57(6):825-830
pubmed: 26959875
J Clin Oncol. 2014 Apr 20;32(12):1218-27
pubmed: 24638000
J Otol. 2018 Dec;13(4):115-121
pubmed: 30671086
Biometrics. 1986 Mar;42(1):121-30
pubmed: 3719049
J Am Geriatr Soc. 2012 Aug;60(8):1487-92
pubmed: 22881367
Lancet. 2017 Dec 9;390(10112):2569-2582
pubmed: 28890157
J Clin Endocrinol Metab. 2010 Jul;95(7):3165-72
pubmed: 20410223
J Nutr Health Aging. 2009 May;13(5):468-72
pubmed: 19390755
Heart Lung. 2013 May-Jun;42(3):163-70
pubmed: 23535142
Toxicol Lett. 2015 Sep 17;237(3):219-27
pubmed: 26101797
Ann Oncol. 1998 Jan;9(1):13-21
pubmed: 9541678
Age Ageing. 2012 Mar;41(2):195-200
pubmed: 22130560
Pediatr Blood Cancer. 2007 Feb;48(2):140-7
pubmed: 16724313
Med Pediatr Oncol. 1995 Apr;24(4):222-30
pubmed: 7700166
J Cancer Surviv. 2017 Feb;11(1):1-12
pubmed: 27262580
J Gerontol A Biol Sci Med Sci. 2001 Mar;56(3):M158-66
pubmed: 11253157
Med Pediatr Oncol. 2002 Apr;38(4):229-39
pubmed: 11920786
J Clin Oncol. 2013 Dec 20;31(36):4496-503
pubmed: 24248696
J Pediatr Hematol Oncol. 2010 Mar;32(2):119-23
pubmed: 20098336
JAMA. 2003 Sep 24;290(12):1583-92
pubmed: 14506117
Ann Intern Med. 2005 Nov 1;143(9):639-47
pubmed: 16263886
Am Soc Clin Oncol Educ Book. 2014;:e423-30
pubmed: 24857133
J Clin Oncol. 2002 Feb 1;20(3):776-90
pubmed: 11821461
Cancer. 2009 May 1;115(9):1984-94
pubmed: 19224548
Toxins (Basel). 2010 Nov;2(11):2490-518
pubmed: 22069563
N Engl J Med. 2000 Jul 6;343(1):16-22
pubmed: 10882764
Curr Opin Clin Nutr Metab Care. 2004 May;7(3):271-7
pubmed: 15075918
J Clin Oncol. 2015 Feb 10;33(5):492-500
pubmed: 25559807
Am J Med. 2005 Nov;118(11):1225-31
pubmed: 16271906
Int J Cancer. 2007 Aug 1;121(3):633-40
pubmed: 17405119
J Pers Soc Psychol. 1986 Dec;51(6):1173-82
pubmed: 3806354
Curr Probl Pediatr Adolesc Health Care. 2003 Aug;33(7):217-42
pubmed: 12902974
Maturitas. 2016 Nov;93:89-99
pubmed: 27125943
J Clin Oncol. 2009 May 10;27(14):2308-18
pubmed: 19364948
Pediatr Blood Cancer. 2013 Jul;60(7):1083-94
pubmed: 23418018
Horm Res. 2008;69(2):65-74
pubmed: 18059086
Med Pediatr Oncol. 1992;20(1):6-12
pubmed: 1727214
Oncol Res. 2012;20(4):179-85
pubmed: 23461065
Eur J Cancer Care (Engl). 2007 May;16(3):231-7
pubmed: 17508942
Med Care. 1992 Jun;30(6):473-83
pubmed: 1593914
J Am Geriatr Soc. 2010 Apr;58(4):681-7
pubmed: 20345864
Am J Med. 2012 Jan;125(1):79-86
pubmed: 22195532
J Clin Oncol. 2009 May 10;27(14):2319-27
pubmed: 19364957
Maturitas. 2015 Feb;80(2):187-91
pubmed: 25542406
J Gerontol A Biol Sci Med Sci. 2001 Mar;56(3):M146-56
pubmed: 11253156
Prev Chronic Dis. 2006 Jan;3(1):A05
pubmed: 16356358
Nat Rev Endocrinol. 2016 Jun;12(6):319-36
pubmed: 27032982
Endocrinol Metab Clin North Am. 2015 Dec;44(4):739-49
pubmed: 26568489
Clin Geriatr Med. 2011 Feb;27(1):39-52
pubmed: 21093721
Complement Ther Clin Pract. 2017 Nov;29:189-193
pubmed: 29122259
Endocr Relat Cancer. 2004 Dec;11(4):589-602
pubmed: 15613441
Clin Nutr. 2014 Feb;33(1):64-8
pubmed: 23631844
Pediatr Hematol Oncol. 2017 Mar;34(2):120-129
pubmed: 28590156
J Pediatr Hematol Oncol. 2000 Mar-Apr;22(2):112-8
pubmed: 10779023
J Gerontol A Biol Sci Med Sci. 2014 Mar;69(3):315-22
pubmed: 23913934
Med Care. 2006 Feb;44(2):149-57
pubmed: 16434914
J Am Coll Surg. 2014 Aug;219(2):265-71
pubmed: 24795268
Pediatr Blood Cancer. 2012 Mar;58(3):334-43
pubmed: 22038641