Overcoming Steric Restrictions of VRC01 HIV-1 Neutralizing Antibodies through Immunization.
Animals
Antibodies, Monoclonal
/ immunology
Antibodies, Neutralizing
/ immunology
B-Lymphocytes
/ immunology
Broadly Neutralizing Antibodies
/ immunology
CD4 Antigens
/ immunology
Female
HIV Antibodies
/ immunology
HIV Infections
/ immunology
HIV-1
/ immunology
Immunization
/ methods
Immunoglobulin Heavy Chains
/ immunology
Male
Mice
Polysaccharides
/ immunology
Receptors, Antigen, B-Cell
/ immunology
env Gene Products, Human Immunodeficiency Virus
/ immunology
426c Env
CDRL1
CDRL3
HIV-1
VRC01
antibody maturation
broadly neutralizing antibodies
germline antibody
germline targeting
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
03 12 2019
03 12 2019
Historique:
received:
28
06
2019
revised:
20
08
2019
accepted:
17
10
2019
entrez:
5
12
2019
pubmed:
5
12
2019
medline:
29
9
2020
Statut:
ppublish
Résumé
Broadly HIV-1 neutralizing VRC01 class antibodies target the CD4-binding site of Env. They are derived from VH1-2
Identifiants
pubmed: 31801073
pii: S2211-1247(19)31393-2
doi: 10.1016/j.celrep.2019.10.071
pmc: PMC6936959
mid: NIHMS1545816
pii:
doi:
Substances chimiques
Antibodies, Monoclonal
0
Antibodies, Neutralizing
0
Broadly Neutralizing Antibodies
0
CD4 Antigens
0
HIV Antibodies
0
Immunoglobulin Heavy Chains
0
Polysaccharides
0
Receptors, Antigen, B-Cell
0
VRC01 monoclonal antibody
0
env Gene Products, Human Immunodeficiency Virus
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
3060-3072.e7Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM120553
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI109632
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI104384
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI138212
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008268
Pays : United States
Informations de copyright
Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.
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