Online monitoring of the cell-specific oxygen uptake rate with an in situ combi-sensor.
Bioprocess monitoring
Cell-specific oxygen uptake rate
OUR
Sensor
Journal
Analytical and bioanalytical chemistry
ISSN: 1618-2650
Titre abrégé: Anal Bioanal Chem
Pays: Germany
ID NLM: 101134327
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
06
08
2019
accepted:
05
11
2019
revised:
28
10
2019
pubmed:
6
12
2019
medline:
15
12
2020
entrez:
6
12
2019
Statut:
ppublish
Résumé
In a biotechnological process, standard monitored process variables are pH, partial oxygen pressure (pO
Identifiants
pubmed: 31802179
doi: 10.1007/s00216-019-02260-9
pii: 10.1007/s00216-019-02260-9
doi:
Substances chimiques
Oxygen
S88TT14065
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2111-2121Subventions
Organisme : Bundesministerium für Bildung und Forschung
ID : 031A616G
Organisme : Allianz Industrie Forschung
ID : 19361 N
Références
Guideline ICHHT. Pharmaceutical development Q8 (R2). Curr step. 2009;4.
Administration F and D. Guidance for industry, PAT-A framework for innovative pharmaceutical development, manufacturing and quality assurance. http//www fda gov/cder/guidance/published html. 2004.
Swann P, Brophy L, Strachan D, Lilly E, Jeffers P. Biomanufacturing technology roadmap - in-line monitoring and real-time release [Internet]. 2017. Available from: https://www.biophorum.com/in-line-monitoring-and-real-time-release/
Valero F, López-Santín J. Online Analysis for industrial bioprocesses: gas analysis. In: Current Developments in Biotechnology and Bioengineering. Elsevier; 2017. p. 649–678.
Heinzle E, Reuss M. Mass spectrometry in biotechnological process analysis and control: Springer; 1987.
Coppella SJ, Dhurjati P. Low-cost computer-coupled fermentor off-gas analysis via quadrupole mass spectrometer. Biotechnol Bioeng. 1987;29(6):679–89.
doi: 10.1002/bit.260290604
Schügerl K. Progress in monitoring, modeling and control of bioprocesses during the last 20 years. J Biotechnol. 2001;85(2):149–73.
doi: 10.1016/S0168-1656(00)00361-8
Garcia-Ochoa F, Gomez E, Santos VE, Merchuk JC. Oxygen uptake rate in microbial processes: an overview. Biochem Eng J. 2010;49(3):289–307.
doi: 10.1016/j.bej.2010.01.011
Jenkins RR, Friedland R, Howald H. The relationship of oxygen uptake to superoxide dismutase and catalase activity in human skeletal muscle. Int J Sports Med. 1984;5(01):11–4.
doi: 10.1055/s-2008-1025872
Behr L, Joeris K, Burnett M, Scheper T. A novel in situ probe for oxygen uptake rate measurement in mammalian cell cultures. Biotechnol Prog. 2012;28(2):581–6.
doi: 10.1002/btpr.741
Biechele P, Busse C, Solle D, Scheper T, Reardon K. Sensor systems for bioprocess monitoring. Eng Life Sci. 2015;15(5):469–88.
doi: 10.1002/elsc.201500014
Busse C, Biechele P, Vries I, Reardon KF, Solle D, Scheper T. Sensors for disposable bioreactors. Eng Life Sci. 2017.
Marquard D, Enders A, Roth G, Rinas U, Scheper T, Lindner P. In situ microscopy for online monitoring of cell concentration in Pichia pastoris cultivations. J Biotechnol. 2016;234:90–8.
doi: 10.1016/j.jbiotec.2016.07.024
Rode B, Endres C, Ran C, Stahl F, Beutel S, Kasper C, et al. Large-scale production and homogenous purification of long chain polysialic acids from E. coli K1. J Biotechnol. 2008;135(2):202–9.
doi: 10.1016/j.jbiotec.2008.03.012
Sandor M, Rüdinger F, Bienert R, Grimm C, Solle D, Scheper T. Comparative study of non-invasive monitoring via infrared spectroscopy for mammalian cell cultivations. J Biotechnol. 2013;168(4):636–45.
doi: 10.1016/j.jbiotec.2013.08.002
Graf A, Claßen J, Solle D, Hitzmann B, Rebner K, Hoehse M. A novel LED-based 2D-fluorescence spectroscopy system for in-line monitoring of Chinese hamster ovary cell cultivations–part I. Eng Life Sci. .
GmbH PPS. O2 Sensorspot SP-PSt3-YAUe [Internet]. [cited 2019 Jul 22]. Available from: https://www.presens.de/de/produkte/detail/o2-sensorspot-sp-pst3-yau.html .
Deshpande RR, Heinzle E. On-line oxygen uptake rate and culture viability measurement of animal cell culture using microplates with integrated oxygen sensors. Biotechnol Lett. 2004;26(9):763–7.
doi: 10.1023/B:BILE.0000024101.57683.6d
Yoon S, Konstantinov KB. Continuous, real-time monitoring of the oxygen uptake rate (OUR) in animal cell bioreactors. Biotechnol Bioeng. 1994;44(8):983–90.
doi: 10.1002/bit.260440815
Goudar CT, Piret JM, Konstantinov KB. Estimating cell specific oxygen uptake and carbon dioxide production rates for mammalian cells in perfusion culture. Biotechnol Prog. 2011;27(5):1347–57.
doi: 10.1002/btpr.646
Deshpande RR, Heinzle E. Online monitoring of oxygen in spinner flasks. Biotechnol Lett. 2009;31(5):665–9.
doi: 10.1007/s10529-009-9919-2
Jorjani P, Ozturk SS. Effects of cell density and temperature on oxygen consumption rate for different mammalian cell lines. Biotechnol Bioeng. 1999;64(3):349–56.
doi: 10.1002/(SICI)1097-0290(19990805)64:3<349::AID-BIT11>3.0.CO;2-V
Ducommun P, Kadouri A, Von Stockar U, Marison IW. On-line determination of animal cell concentration in two industrial high-density culture processes by dielectric spectroscopy. Biotechnol Bioeng. 2002;77(3):316–23.
doi: 10.1002/bit.1197
Brischwein M, Motrescu ER, Cabala E, Otto AM, Grothe H, Wolf B. Functional cellular assays with multiparametric silicon sensor chips. Lab Chip. 2003;3(4):234–40.
doi: 10.1039/b308888j
Wiest J, Stadthagen T, Schmidhuber M, Brischwein M, Ressler J, Raeder U, et al. Intelligent mobile lab for metabolics in environmental monitoring. Anal Lett. 2006;39(8):1759–71.
doi: 10.1080/00032710600714089