Crucial Roles of Two Hydrated Mg
RNA
magnesium
oligonucleotides
reaction mechanisms
structure-function relationships
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
10 02 2020
10 02 2020
Historique:
received:
30
09
2019
pubmed:
6
12
2019
medline:
9
1
2021
entrez:
6
12
2019
Statut:
ppublish
Résumé
Pistol ribozymes constitute a new class of small self-cleaving RNAs. Crystal structures have been solved, providing three-dimensional snapshots along the reaction coordinate of pistol phosphodiester cleavage, corresponding to the pre-catalytic state, a vanadate mimic of the transition state, and the product. The results led to the proposed underlying chemical mechanism. Importantly, a hydrated Mg
Identifiants
pubmed: 31804735
doi: 10.1002/anie.201912522
pmc: PMC7027511
doi:
Substances chimiques
Ions
0
Phosphates
0
RNA, Catalytic
0
Water
059QF0KO0R
Magnesium
I38ZP9992A
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2837-2843Subventions
Organisme : Austrian Science Fund FWF
ID : M 2517
Pays : Austria
Organisme : Austrian Science Fund FWF
ID : P 27947
Pays : Austria
Organisme : Austrian Science Fund FWF
ID : P 31691
Pays : Austria
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Informations de copyright
© 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.
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