Associations between serum levels of insulin-like growth factor-I and bone mineral acquisition in pubertal children: a 3-year follow-up study in Hamamatsu, Japan.
Bone development
Densitometry
General population
Somatomedins
Journal
Journal of physiological anthropology
ISSN: 1880-6805
Titre abrégé: J Physiol Anthropol
Pays: England
ID NLM: 101269653
Informations de publication
Date de publication:
05 Dec 2019
05 Dec 2019
Historique:
received:
06
02
2019
accepted:
19
11
2019
entrez:
7
12
2019
pubmed:
7
12
2019
medline:
7
1
2020
Statut:
epublish
Résumé
Epidemiological data regarding the association between serum levels of IGF-I and bone mineral acquisition during childhood are scarce. Here, we investigated the association between serum levels of IGF-I and bone status during puberty. We analyzed prospective 3-year follow-up data of 254 community-dwelling children who completed both baselines (at age 11.2 years) and follow-up (at age 14.2 years) surveys in Hamamatsu, Japan. Total body (TB) bone area and bone mineral parameters were assessed using dual-energy X-ray absorptiometry. During the 3-year follow-up period, there were significant (P < 0.05) increases in total body less head (TBLH) areal bone mineral density (aBMD), TBLH bone mineral content (BMC), and TB bone area, and a significant decrease in TB bone mineral apparent density (BMAD, volumetric bone mineral density, vBMD). IGF-I levels showed significant positive relationships with TBLH BMC and TBLH aBMD at both baseline and follow-up. TBLH aBMD in boys and TB BMAD in girls at follow-up showed significant increases from the lowest to highest quartiles of baseline IGF-I levels after adjusting for confounding factors. Similarly, changes in TBLH aBMD in boys and TB BMAD in girls during the 3-year follow-up period showed significant increases from the lowest to highest quartiles of baseline IGF-I levels after adjusting for confounding factors. These results suggest that pubertal children with high levels of serum IGF-I tended to have high bone mineral acquisition later on.
Sections du résumé
BACKGROUND
BACKGROUND
Epidemiological data regarding the association between serum levels of IGF-I and bone mineral acquisition during childhood are scarce. Here, we investigated the association between serum levels of IGF-I and bone status during puberty.
METHODS
METHODS
We analyzed prospective 3-year follow-up data of 254 community-dwelling children who completed both baselines (at age 11.2 years) and follow-up (at age 14.2 years) surveys in Hamamatsu, Japan. Total body (TB) bone area and bone mineral parameters were assessed using dual-energy X-ray absorptiometry.
RESULTS
RESULTS
During the 3-year follow-up period, there were significant (P < 0.05) increases in total body less head (TBLH) areal bone mineral density (aBMD), TBLH bone mineral content (BMC), and TB bone area, and a significant decrease in TB bone mineral apparent density (BMAD, volumetric bone mineral density, vBMD). IGF-I levels showed significant positive relationships with TBLH BMC and TBLH aBMD at both baseline and follow-up. TBLH aBMD in boys and TB BMAD in girls at follow-up showed significant increases from the lowest to highest quartiles of baseline IGF-I levels after adjusting for confounding factors. Similarly, changes in TBLH aBMD in boys and TB BMAD in girls during the 3-year follow-up period showed significant increases from the lowest to highest quartiles of baseline IGF-I levels after adjusting for confounding factors.
CONCLUSIONS
CONCLUSIONS
These results suggest that pubertal children with high levels of serum IGF-I tended to have high bone mineral acquisition later on.
Identifiants
pubmed: 31806017
doi: 10.1186/s40101-019-0210-5
pii: 10.1186/s40101-019-0210-5
pmc: PMC6896327
doi:
Substances chimiques
IGF1 protein, human
0
Insulin-Like Growth Factor I
67763-96-6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
16Subventions
Organisme : Japan Society for Promotion of Science
ID : 21657068
Organisme : Japan Society for Promotion of Science
ID : 22370092
Organisme : Japan Society for Promotion of Science
ID : 24370101
Organisme : Japan Society for Promotion of Science
ID : 26291100
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