Visualization of Nigrosome 1 from the Viewpoint of Anatomic Structure.
Journal
AJNR. American journal of neuroradiology
ISSN: 1936-959X
Titre abrégé: AJNR Am J Neuroradiol
Pays: United States
ID NLM: 8003708
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
29
06
2019
accepted:
10
10
2019
pubmed:
7
12
2019
medline:
17
9
2020
entrez:
7
12
2019
Statut:
ppublish
Résumé
Parkinson disease is related to neurodegeneration and iron deposition in the substantia nigra pars compacta and nigrosome 1. However, visualization of nigrosome 1 via MR imaging is poor owing to the bilateral asymmetry, regardless of whether it is healthy. We focused on the magic angle and susceptibility effect and evaluated the anatomic slant structure of nigrosome 1 by tilting subjects' heads in the B To investigate the effectiveness of the magic angle, we tilted the volunteers' heads to the right and left in the B The heads tilted to the right and left showed significantly higher contrasts of nigrosome 1 and the substantia nigra pars compacta than the nontilted heads. No significant differences were observed in the visualization and susceptibility between the right nigrosome 1 and left nigrosome 1 for each head tilt. The effect of the magic angle was remarkable in the nontilted heads. This finding was supported by quantitative susceptibility mapping because the anatomic slant structure of nigrosome 1 was coherent between the axis of nigrosome 1 and the magic angle. The asymmetric visualization of nigrosome 1 is affected by the magic angle and susceptibility. The anatomic slant structure of nigrosome 1 causes these challenges in visualization.
Sections du résumé
BACKGROUND AND PURPOSE
Parkinson disease is related to neurodegeneration and iron deposition in the substantia nigra pars compacta and nigrosome 1. However, visualization of nigrosome 1 via MR imaging is poor owing to the bilateral asymmetry, regardless of whether it is healthy. We focused on the magic angle and susceptibility effect and evaluated the anatomic slant structure of nigrosome 1 by tilting subjects' heads in the B
MATERIALS AND METHODS
To investigate the effectiveness of the magic angle, we tilted the volunteers' heads to the right and left in the B
RESULTS
The heads tilted to the right and left showed significantly higher contrasts of nigrosome 1 and the substantia nigra pars compacta than the nontilted heads. No significant differences were observed in the visualization and susceptibility between the right nigrosome 1 and left nigrosome 1 for each head tilt. The effect of the magic angle was remarkable in the nontilted heads. This finding was supported by quantitative susceptibility mapping because the anatomic slant structure of nigrosome 1 was coherent between the axis of nigrosome 1 and the magic angle.
CONCLUSIONS
The asymmetric visualization of nigrosome 1 is affected by the magic angle and susceptibility. The anatomic slant structure of nigrosome 1 causes these challenges in visualization.
Identifiants
pubmed: 31806600
pii: ajnr.A6338
doi: 10.3174/ajnr.A6338
pmc: PMC6975307
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
86-91Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2020 by American Journal of Neuroradiology.
Références
Neuroimage. 2015 Feb 15;107:163-174
pubmed: 25463463
Magn Reson Med. 2010 Jan;63(1):194-206
pubmed: 19953507
Magn Reson Med. 2015 Jan;73(1):82-101
pubmed: 25044035
Neurobiol Aging. 2002 May-Jun;23(3):433-41
pubmed: 11959406
NMR Biomed. 2017 Apr;30(4):
pubmed: 27060968
Magn Reson Med. 2016 Jun;75(6):2455-63
pubmed: 27018784
Magn Reson Imaging. 2017 Oct;42:37-42
pubmed: 28526432
Neuroimage. 2014 Jan 1;84:1032-41
pubmed: 24004692
Brain. 1999 Aug;122 ( Pt 8):1421-36
pubmed: 10430829
Radiology. 1993 Jul;188(1):23-5
pubmed: 7685531
AJNR Am J Neuroradiol. 2004 Mar;25(3):431-40
pubmed: 15037469
Top Magn Reson Imaging. 2006 Feb;17(1):31-40
pubmed: 17179895
Neuroimage. 2012 Feb 1;59(3):2625-35
pubmed: 21925274
Brain. 2000 Dec;123 Pt 12:2423-31
pubmed: 11099445
Magn Reson Med. 2009 May;61(5):1066-72
pubmed: 19253372
Biophys J. 1993 Mar;64(3):803-12
pubmed: 8386018
Dementia. 1993 Mar-Apr;4(2):61-5
pubmed: 8358514
AJNR Am J Neuroradiol. 2015 Mar;36(3):461-6
pubmed: 25376811
J Magn Reson Imaging. 2001 Apr;13(4):534-46
pubmed: 11276097
Magn Reson Med. 2012 Jan;67(1):137-47
pubmed: 21671269
Top Magn Reson Imaging. 2006 Feb;17(1):5-17
pubmed: 17179893
Brain. 2010 Nov;133(11):3423-33
pubmed: 20736190
Brain. 1999 Aug;122 ( Pt 8):1437-48
pubmed: 10430830
J Magn Reson Imaging. 2017 Aug;46(2):528-536
pubmed: 27859983
AJNR Am J Neuroradiol. 2015 Nov;36(11):2010-6
pubmed: 26294646
Neuroimage. 2015 Mar;108:111-22
pubmed: 25536496
Neuroimage. 2014 Nov 15;102 Pt 2:789-97
pubmed: 25192653
J Magn Reson Imaging. 2008 Nov;28(5):1061-7
pubmed: 18972346
Brain. 1999 Apr;122 ( Pt 4):667-73
pubmed: 10219780
Neurology. 2009 Apr 21;72(16):1378-84
pubmed: 19129507
Neurology. 2013 Aug 6;81(6):534-40
pubmed: 23843466
NMR Biomed. 2017 Apr;30(4):
pubmed: 27731911
Radiology. 2009 Jul;252(1):165-72
pubmed: 19561255
J Neurol Neurosurg Psychiatry. 2004 Mar;75(3):481-4
pubmed: 14966170
Neuroimage. 2012 Feb 1;59(3):2560-8
pubmed: 21925276
PLoS One. 2014 Apr 07;9(4):e93814
pubmed: 24710392