Compelling therapy of LVH: straight (and not-so-straight) inferences from evidence.
ACE-inhibitors
Amlodipine
Calcium channel blockers
Chlorthalidone
Guidelines
Heart failure
Hypertension
Left ventricle hypertrophy
Thiazide diuretics
Journal
Clinical hypertension
ISSN: 2056-5909
Titre abrégé: Clin Hypertens
Pays: England
ID NLM: 101669508
Informations de publication
Date de publication:
2019
2019
Historique:
received:
28
08
2019
accepted:
18
10
2019
entrez:
7
12
2019
pubmed:
7
12
2019
medline:
7
12
2019
Statut:
epublish
Résumé
We have read with interest the Korean Society of Hypertension guidelines for the management of hypertension and congratulate the Society for an extensive review of literature while drafting the guidelines. The guidelines indicate preferring ACE-I and CCB over diuretics in patients with left ventricle hypertrophy. However, in landmark head-to-head comparison trials, the thiazide-like diuretic chlorthalidone has been shown to be superior to ACE-I and CCB in decreasing left ventricle mass and preventing heart failure in hypertensive patients. Also, we put forth the paradoxical finding that mere regression of LVH may not always translate into reduction in risk of HF; and that the pleiotropic effects of chlorthalidone may be the explanation behind its beneficial action in HF.
Identifiants
pubmed: 31807315
doi: 10.1186/s40885-019-0131-y
pii: 131
pmc: PMC6857286
doi:
Types de publication
Journal Article
Langues
eng
Pagination
25Informations de copyright
© The Author(s). 2019.
Déclaration de conflit d'intérêts
Competing interestsAuthors are affiliated to Ipca Laboratories Limited and are involved in research studies on chlorthalidone.
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