Choroidal structural changes in preterm children with and without retinopathy of prematurity.
choroidal thickness
choroidal vascularity index
optical coherence tomography
preterm children
retinopathy of prematurity
Journal
Acta ophthalmologica
ISSN: 1755-3768
Titre abrégé: Acta Ophthalmol
Pays: England
ID NLM: 101468102
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
09
06
2019
accepted:
10
11
2019
pubmed:
7
12
2019
medline:
7
12
2019
entrez:
7
12
2019
Statut:
ppublish
Résumé
Evaluate choroidal structural changes in preterm children with and without retinopathy of prematurity (ROP) using image binarization technique on swept-source optical coherence tomography (SS-OCT) scans. Prospective case-control study. Forty-one (79 eyes) children aged 5-15 years with a history of preterm birth and 33 (63 eyes) age-matched full-term children were recruited. Demographics including gestational age at birth, birth weight and history of ROP were documented. All subjects had undergone complete eye examinations, including best-corrected visual acuity and SS-OCT imaging. Subfoveal choroidal thickness (SFCT) was calculated, and images were binarized to obtain stromal and luminal areas (LA). The choroidal vascularity index (CVI) was derived from the proportion of LA to the total subfoveal choroidal area. There were no significant differences in SFCT between the preterm children with (286.63 ± 83.98 μm) or without (306.59 ± 77.29 μm) ROP and the full-term children (311.82 ± 42.87; p = 0.20 and 0.67, respectively). The CVI was significantly reduced in the preterm children with ROP (68.66 ± 3.24%; p = 0.005) compared with the CVI in the full-term control group (71.37 ± 3.63%); however, the CVI in the preterm children without ROP (71.68 ± 3.09%; p = 0.93) was not significantly affected. The reduced CVI in preterm children with ROP may indicate compromised choroidal vascularity. The CVI was found to be a more sensitive OCT biomarker than the SFCT and may be helpful in evaluating associated choroidal structural changes in preterm children, especially those with a history of ROP.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e611-e616Informations de copyright
© 2019 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.
Références
Agrawal R, Gupta P, Tan KA, Cheung CM, Wong TY & Cheng CY (2016a): Choroidal vascularity index as a measure of vascular status of the choroid: measurements in healthy eyes from a population-based study. Sci Rep 6: 21090.
Agrawal R, Chhablani J, Tan KA, Shah S, Sarvaiya C & Banker A (2016b): Choroidal vascularity index in central serous chorioretinopathy. Retina 36: 1646-1651.
Akerblom H, Larsson E, Eriksson U & Holmstrom G (2011): Central macular thickness is correlated with gestational age at birth in prematurely born children. Br J Ophthalmol 95: 799-803.
Åkerblom H, Andreasson S, Larsson E & Holmström G (2014): Photoreceptor function in school-aged children is affected by preterm birth. Transl Vis Sci Technol 3: 7.
Bowl W, Bowl M, Schweinfurth S, Holve K, Andrassi-Darida M, Stieger K & Lorenz B (2018): Choroidal thickness with swept-source optical coherence tomography versus foveal morphology in young children with a history of prematurity. Ophthalmic Res 60: 205-213.
Erol MK, Coban DT, Ozdemir O, Dogan B, Tunay ZO & Bulut M (2016): Choroidal thickness in infants with retinopathy of prematurity. Retina 36: 1191-1198.
Fielder A, Blencowe H, O'connor A & Gilbert C (2015): Impact of retinopathy of prematurity on ocular structures and visual functions. Arch Dis Child Fetal Neonatal Ed 100: F179-F184.
Fieß A, Janz J, Schuster AK, Kölb-Keerl R, Knuf M, Kirchhof B, Muether PS & Bauer J (2017): Macular morphology in former preterm and full-term infants aged 4 to 10 years. Graefes Arch Clin Exp Ophthalmol 255: 1433-1442.
Fulton AB, Hansen RM, Moskowitz A & Akula JD (2009): The neurovascular retina in retinopathy of prematurity. Prog Retin Eye Res 28: 452-482.
Geldof CJ, Van Wassenaer-Leemhuis AG, Dik M, Kok JH & Oosterlaan J (2015): A functional approach to cerebral visual impairments in very preterm/very-low-birth-weight children. Pediat Res 78: 190-197.
Goldenberg D, Moisseiev E, Goldstein M, Loewenstein A & Barak A (2012): Enhanced depth imaging optical coherence tomography: choroidal thickness and correlations with age, refractive error, and axial length. Ophthalmic Surg Lasers Imaging 43: 296-301.
Hughes S, Yang H & Chan-Ling T (2000): Vascularization of the human fetal retina: roles of vasculogenesis and angiogenesis. Invest Ophthalmol Vis Sci 41: 1217-1228.
Kara N, Demircan A, Karatas G, Ozgurhan EB, Tatar G, Karakucuk Y, Basci A & Demirok A (2014): Effects of two commonly used mydriatics on choroidal thickness: direct and crossover effects. J Ocul Pharmacol Ther 30: 366-370.
Li XQ, Larsen M & Munch IC (2011): Subfoveal choroidal thickness in relation to sex and axial length in 93 Danish university students. Invest Ophthalmol Vis Sci 52: 8438-8441.
Ludwig CA, Chen TA, Hernandez-Boussard T, Moshfeghi AA & Moshfeghi DM (2017): The epidemiology of retinopathy of prematurity in the United States. Ophthalmic Surg Lasers Imaging Retina 48: 553-562.
Lutty GA & McLeod DS (2018): Development of the hyaloid, choroidal and retinal vasculatures in the fetal human eye. Prog Retin Eye Res 62: 58-76.
Marques NS, Barros S, Miranda A, Cardoso J, Parreira S, Fonseca T, Donaire N & Campos N. (2016): Evaluation of retinal, choroidal thickness and retinal pigmented epithelium using cirrus SD-OCT in Portuguese children with history of preterm birth. Vis Pan-Am 15: 56-60.
Nickla DL & Wallman J (2010): The multifunctional choroid. Prog Retin Eye Res 29: 144-168.
Park KA & Oh SY (2012): Analysis of spectral-domain optical coherence tomography in preterm children: retinal layer thickness and choroidal thickness profiles. Invest Ophthalmol Vis Sci 53: 7201-7207.
Ratra D, Tan R, Jaishankar D, Khandelwal N, Gupta A, Chhablani J & Agrawal R (2018): Choroidal structural changes and vascularity index in stargardt disease on swept source optical coherence tomography. Retina 38: 2359-2400.
Rivera JC, Holm M, Austeng D et al. (2017): Retinopathy of prematurity: inflammation, choroidal degeneration, and novel promising therapeutic strategies. J Neuroinflammation 14: 165.
Salvin JH, Lehman SS, Jin J & Hendricks DH (2010): Update on retinopathy of prematurity: treatment options and outcomes. Curr Opin Ophthalmol 21: 329-334.
Shao Z, Dorfman AL, Seshadri S et al. (2011): Choroidal involution is a key component of oxygen-induced retinopathy. Invest Ophthalmol Vis Sci 52: 6238-6248.
Tan CS, Ouyang Y, Ruiz H & Sadda SR (2012): Diurnal variation of choroidal thickness in normal, healthy subjects measured by spectral domain optical coherence tomography. Invest Opthalmol Vis Sci 53: 261-266.
Tan KA, Laude A, Yip V, Loo E, Wong EP & Agrawal R (2016): Choroidal vascularity index - a novel optical coherence tomography parameter for disease monitoring in diabetes mellitus? Acta Ophthalmol 94: e612-e616.
Tekavčič Pompe M & Šuštar M (2019): Flicker electroretinogram recorded with portable ERG device in prematurely born schoolchildren with and without ROP. Doc Ophthalmol 139: 59-65.
Wei X, Ting DSW, Ng WY, Khandelwal N, Agrawal R & Cheung CMG (2017): Choroidal vascularity index - a novel optical coherence tomography based parameter in patients with exudative age-related macular degeneration. Retina 37: 1120-1125.
Wu WC, Lin RI, Shih CP et al. (2012): Visual acuity, optical components & macular abnormalities in patients with a history of retinopathy of prematurity. Ophthalmology 119: 1907-1916.
Wu WC, Shih CP, Wang NK et al. (2013): Choroidal thickness in patients with a history of retinopathy of prematurity. Ophthalmol JAMA 131: 1451-1458.
Zhou TE, Rivera JC, Bhosle VK et al. (2016): Choroidal involution is associated with a progressive degeneration of the outer retinal function in a model of retinopathy of prematurity: early role for IL-1β. Am Pathol J 186: 3100-3116.