Checkpoint inhibitors in AML: are we there yet?
Antineoplastic Agents, Immunological
/ therapeutic use
B7-H1 Antigen
/ antagonists & inhibitors
CTLA-4 Antigen
/ antagonists & inhibitors
Hematologic Neoplasms
/ immunology
Humans
Immunotherapy
Leukemia, Myeloid, Acute
/ immunology
Neoplasm Proteins
/ antagonists & inhibitors
Programmed Cell Death 1 Receptor
/ antagonists & inhibitors
CTLA-4
PD-1
PD-L1
acute myeloid leukemia
checkpoint inhibitors
Journal
British journal of haematology
ISSN: 1365-2141
Titre abrégé: Br J Haematol
Pays: England
ID NLM: 0372544
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
pubmed:
7
12
2019
medline:
7
7
2020
entrez:
7
12
2019
Statut:
ppublish
Résumé
Immunotherapy is distinct from traditional chemotherapy in that it acts on immune cells rather than cancer cells themselves. Monoclonal antibodies targeting immune checkpoints on T cells - CTLA-4 and PD-1 - and PD-L1 on the cells of immune microenvironment are now approved for clinical use in several solid tumors and hematological malignancies. This article provides a general overview of the use of checkpoint inhibitors in hematologic malignancies with a special focus in acute myeloid leukemia.
Identifiants
pubmed: 31808941
doi: 10.1111/bjh.16358
pmc: PMC9549702
mid: NIHMS1832010
doi:
Substances chimiques
Antineoplastic Agents, Immunological
0
B7-H1 Antigen
0
CD274 protein, human
0
CTLA-4 Antigen
0
CTLA4 protein, human
0
Neoplasm Proteins
0
PDCD1 protein, human
0
Programmed Cell Death 1 Receptor
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
159-167Subventions
Organisme : NCI NIH HHS
ID : P01 CA023766
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA228308
Pays : United States
Organisme : Carlos III Health Institute
Pays : International
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : Generalitat de Catalunya
ID : BDNS357800
Pays : International
Organisme : NIH HHS
ID : P01 CA23766
Pays : United States
Organisme : NIH HHS
ID : P30 CA008748
Pays : United States
Informations de copyright
© 2019 British Society for Haematology and John Wiley & Sons Ltd.
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