Prenatal polyunsaturated fatty acids and child asthma: Effect modification by maternal asthma and child sex.

Asthma / epidemiology Child Child, Preschool Fatty Acids, Omega-3 / blood Fatty Acids, Omega-6 / blood Female Humans Male Mothers Pregnancy Prenatal Exposure Delayed Effects / blood Risk Factors Sex Characteristics
Polyunsaturated fatty acid childhood asthma prenatal sex-specific effects

Journal

The Journal of allergy and clinical immunology
ISSN: 1097-6825
Titre abrégé: J Allergy Clin Immunol
Pays: United States
ID NLM: 1275002

Informations de publication

Date de publication:
03 2020
Historique:
received: 28 06 2019
revised: 08 10 2019
accepted: 25 10 2019
pubmed: 7 12 2019
medline: 1 12 2020
entrez: 7 12 2019
Statut: ppublish

Résumé

Findings on prenatal polyunsaturated fatty acid (PUFA) intake and child wheeze and asthma have been inconsistent. We sought to examine associations between prenatal PUFA status and child wheeze/asthma and modifying effects of maternal asthma/atopy, child sex, and maternal race. Analyses included 1019 mother-child dyads with omega-3 (n-3) and omega-3 (n-6) PUFAs measured in second-trimester plasma; n-6/n-3 ratios were calculated. Child wheeze/asthma outcomes ascertained at age 4 to 6 years included ever physician-diagnosed asthma, current wheeze (symptoms past 12 months), current asthma (diagnosis and medication and/or symptoms past 12 months), and current diagnosed asthma. Each PUFA indicator and outcome was analyzed in separate models using modified Poisson regression with interaction terms. In quartile (Q) analyses, higher n-6 PUFAs were associated with increased risk of ever (risk ratio [RR] high vs low [RR Q4 vs Q1], 1.70; 95% CI, 1.07-2.71) and current (RR Q4 vs Q1, 1.70; 95% CI, 1.07-2.71) diagnosed asthma, whereas n-3 PUFAs were associated with lower risk (RR Q4 vs Q1, 0.59; 95% CI, 0.33-1.03) of current diagnosed asthma (P Associations between prenatal PUFA status and childhood wheeze/asthma were modified by maternal history of asthma and child sex.

Sections du résumé

BACKGROUND
Findings on prenatal polyunsaturated fatty acid (PUFA) intake and child wheeze and asthma have been inconsistent.
OBJECTIVE
We sought to examine associations between prenatal PUFA status and child wheeze/asthma and modifying effects of maternal asthma/atopy, child sex, and maternal race.
METHODS
Analyses included 1019 mother-child dyads with omega-3 (n-3) and omega-3 (n-6) PUFAs measured in second-trimester plasma; n-6/n-3 ratios were calculated. Child wheeze/asthma outcomes ascertained at age 4 to 6 years included ever physician-diagnosed asthma, current wheeze (symptoms past 12 months), current asthma (diagnosis and medication and/or symptoms past 12 months), and current diagnosed asthma. Each PUFA indicator and outcome was analyzed in separate models using modified Poisson regression with interaction terms.
RESULTS
In quartile (Q) analyses, higher n-6 PUFAs were associated with increased risk of ever (risk ratio [RR] high vs low [RR Q4 vs Q1], 1.70; 95% CI, 1.07-2.71) and current (RR Q4 vs Q1, 1.70; 95% CI, 1.07-2.71) diagnosed asthma, whereas n-3 PUFAs were associated with lower risk (RR Q4 vs Q1, 0.59; 95% CI, 0.33-1.03) of current diagnosed asthma (P
CONCLUSIONS
Associations between prenatal PUFA status and childhood wheeze/asthma were modified by maternal history of asthma and child sex.

Identifiants

DOI: 10.1016/j.jaci.2019.10.039 PMID: 31809758 PMC: PMC7341550
pubmed: 31809758
pii: S0091-6749(19)31622-7
doi: 10.1016/j.jaci.2019.10.039
pmc: PMC7341550
mid: NIHMS1600786
pii:
doi:

Substances chimiques

Fatty Acids, Omega-3 0
Fatty Acids, Omega-6 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

800-807.e4

Subventions

Organisme : NIDDK NIH HHS
ID : P30 DK020593
Pays : United States
Organisme : NIEHS NIH HHS
ID : R00 ES027496
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL109977
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL132338
Pays : United States

Informations de copyright

Copyright © 2019 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

Références

J Lipid Res. 1964 Oct;5:600-8
pubmed: 14221106
Lipids. 2003 Apr;38(4):343-52
pubmed: 12848278
Br J Nutr. 2012 Aug;108(4):720-32
pubmed: 22067943
Am J Clin Nutr. 2011 May;93(5):950-62
pubmed: 21367944
Respir Res. 2009 Jun 12;10:49
pubmed: 19519921
J Allergy Clin Immunol. 2004 Sep;114(3):531-7
pubmed: 15356553
Allergy. 2008 Jan;63(1):47-57
pubmed: 17822448
Prog Lipid Res. 2008 Mar;47(2):147-55
pubmed: 18198131
N Engl J Med. 1990 Sep 6;323(10):645-55
pubmed: 2166915
Pediatr Pulmonol. 2015 Dec;50(12):1159-69
pubmed: 25906765
Ann Epidemiol. 2013 Nov;23(11):674-80
pubmed: 24094480
Proc Nutr Soc. 2010 Aug;69(3):373-80
pubmed: 20462467
Allergy. 2012 Aug;67(8):1041-59
pubmed: 22712878
Acta Paediatr. 2009 Sep;98(9):1461-7
pubmed: 19489765
Br J Nutr. 2011 Aug;106(3):441-50
pubmed: 21443816
BMJ. 2012 Jan 30;344:e184
pubmed: 22294737
Clin Exp Allergy. 2003 Apr;33(4):412-5
pubmed: 12680853
World Allergy Organ J. 2018 Jun 15;11(1):10
pubmed: 29977437
Br J Nutr. 2018 Jan;119(2):202-210
pubmed: 29359683
Am J Clin Nutr. 2016 Jan;103(1):128-43
pubmed: 26675770
J Allergy Clin Immunol. 2018 Mar;141(3):886-892.e3
pubmed: 28712803
Pediatr Allergy Immunol. 2018 Mar;29(2):144-150
pubmed: 29168294
Am J Clin Nutr. 2018 Aug 1;108(2):211-227
pubmed: 29931035
Int J Epidemiol. 2017 Oct 1;46(5):1465-1477
pubmed: 28338907
J Biol Chem. 1957 May;226(1):497-509
pubmed: 13428781
Eur J Clin Nutr. 2013 Apr;67(4):353-9
pubmed: 23443828
Environ Health. 2013 Dec 02;12:102
pubmed: 24295221
Eur J Clin Nutr. 2013 Jun;67(6):658-63
pubmed: 23549201
Clin Exp Allergy. 2016 Mar;46(3):461-71
pubmed: 26285050
Nutrients. 2013 May 03;5(5):1511-30
pubmed: 23645026
Thorax. 2008 Jun;63(6):507-13
pubmed: 18198206
Eur Respir J. 1995 Mar;8(3):483-91
pubmed: 7789502
J Nutr. 2009 Oct;139(10):1956-63
pubmed: 19710161
J Allergy Clin Immunol Pract. 2019 Feb;7(2):529-538.e8
pubmed: 30145365
Vital Health Stat 10. 2013 Dec;(258):1-81
pubmed: 24784481
Am J Epidemiol. 2004 Apr 1;159(7):702-6
pubmed: 15033648
Thorax. 2009 Sep;64(9):815-21
pubmed: 19497922
Paediatr Perinat Epidemiol. 2009 Sep;23(5):446-53
pubmed: 19689495
Proc Nutr Soc. 2008 Feb;67(1):19-27
pubmed: 18234128
Clin Exp Allergy. 2011 Mar;41(3):407-16
pubmed: 21255139
N Engl J Med. 1995 Jan 19;332(3):133-8
pubmed: 7800004
Am J Clin Nutr. 2011 Dec;94(6 Suppl):1914S-1919S
pubmed: 22089435
Br J Nutr. 2006 Oct;96(4):774-90
pubmed: 17010239
Pediatr Allergy Immunol. 2014 Jun;25(4):344-50
pubmed: 24576150
Exp Lung Res. 2014 Feb;40(1):30-9
pubmed: 24354441
Pediatr Allergy Immunol. 2011 Aug;22(5):505-14
pubmed: 21332799
Pediatr Allergy Immunol. 2011 Dec;22(8):827-35
pubmed: 21929596
Pediatrics. 1998 Jul;102(1 Pt 1):84-90
pubmed: 9651418
Curr Allergy Asthma Rep. 2018 Sep 18;18(11):58
pubmed: 30229317
J Nutr. 2012 Mar;142(3):592S-599S
pubmed: 22279140
Eur Respir J. 1997 Jan;10(1):6-12
pubmed: 9032484
Am J Clin Nutr. 2008 Jul;88(1):167-75
pubmed: 18614738
Allergy. 2013 Nov;68(11):1370-6
pubmed: 24111502
Clin Dev Immunol. 2012;2012:474613
pubmed: 23049600

Auteurs

Maria José Rosa (MJ)

Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address: maria.rosa@mssm.edu.

Terryl J Hartman (TJ)

Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Ga.

Margaret Adgent (M)

Division of General Pediatrics, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tenn.

Kourtney Gardner (K)

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn.

Tebeb Gebretsadik (T)

Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tenn.

Paul E Moore (PE)

Division of Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tenn.

Robert L Davis (RL)

Center for Biomedical Informatics, University of Tennessee Health Sciences Center, Memphis, Tenn.

Kaja Z LeWinn (KZ)

Department of Psychiatry, Weill Institute for the Neurosciences, University of California San Francisco, San Francisco, Calif.

Nicole R Bush (NR)

Department of Psychiatry, Weill Institute for the Neurosciences, University of California San Francisco, San Francisco, Calif; Department of Pediatrics, University of California San Francisco, San Francisco, Calif.

Frances Tylavsky (F)

Department of Preventive Medicine, University of Tennessee Health Science Center in Memphis, Memphis, Tenn.

Rosalind J Wright (RJ)

Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY; Institute for Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, NY; Kravis Children's Hospital, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY.

Kecia N Carroll (KN)

Division of General Pediatrics, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tenn.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Hypersensibilité respiratoire › Asthme › Prenatal polyunsaturated fatty acids and child...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Prenatal polyunsaturated fatty acids and child...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Prenatal polyunsaturated fatty acids and child...
questionsmedicales.fr › Lipides › Huiles › Huiles de poisson › Acides gras omega-3 › Prenatal polyunsaturated fatty acids and child...
questionsmedicales.fr › Lipides › Acides gras › Acides gras insaturés › Acides gras omega-6 › Prenatal polyunsaturated fatty acids and child...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Prenatal polyunsaturated fatty acids and child...
questionsmedicales.fr › Personnes › Parents › Mères › Prenatal polyunsaturated fatty acids and child...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Prenatal polyunsaturated fatty acids and child...
questionsmedicales.fr › Maladies urogénitales › Maladies de l'appareil urogénital féminin et complications de la grossesse › Complications de la grossesse › Lésions prénatales › Effets différés de l'exposition prénatale à des facteurs de risque › Prenatal polyunsaturated fatty acids and child...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Prenatal polyunsaturated fatty acids and child...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Caractères sexuels › Prenatal polyunsaturated fatty acids and child...