Higher resting-state BNST-CeA connectivity is associated with greater corrugator supercilii reactivity to negatively valenced images.
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
15 02 2020
15 02 2020
Historique:
received:
22
07
2019
revised:
31
10
2019
accepted:
01
12
2019
pubmed:
7
12
2019
medline:
4
3
2021
entrez:
7
12
2019
Statut:
ppublish
Résumé
The bed nucleus of the stria terminalis (BNST) and central nucleus of the amygdala (CeA) are hypothesized to be the output nodes of the extended amygdala threat response, integrating multiple signals to coordinate the threat response via outputs to the hypothalamus and brainstem. The BNST and CeA are structurally and functionally connected, suggesting interactions between these regions may regulate how the response to provocation unfolds. However, the relationship between human BNST-CeA connectivity and the behavioral response to affective stimuli is little understood. To investigate whether individual differences in BNST-CeA connectivity are related to the affective response to negatively valenced stimuli, we tested relations between resting-state BNST-CeA connectivity and both facial electromyographic (EMG) activity of the corrugator supercilii muscle and eyeblink startle magnitude during affective image presentation within the Refresher sample of the Midlife in the United States (MIDUS) study. We found that higher right BNST-CeA connectivity was associated with greater corrugator activity to negative, but not positive, images. There was a trend-level association between right BNST-CeA connectivity and trait negative affect. Eyeblink startle magnitude was not significantly related to BNST-CeA connectivity. These results suggest that functional interactions between BNST and CeA contribute to the behavioral response to negative emotional events.
Identifiants
pubmed: 31809887
pii: S1053-8119(19)31019-5
doi: 10.1016/j.neuroimage.2019.116428
pmc: PMC7058151
mid: NIHMS1062790
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
116428Subventions
Organisme : NICHD NIH HHS
ID : P30 HD003352
Pays : United States
Organisme : NCCIH NIH HHS
ID : F32 AT010101
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH018931
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH043454
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG020166
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD090256
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG051426
Pays : United States
Informations de copyright
Copyright © 2019. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of competing interest R.J.D. serves on the board of directors for the non-profit organization Healthy Minds Innovations. The other authors report no perceived or real conflicts of interest.
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