IL-6 is present in beta and alpha cells in human pancreatic islets: Expression is reduced in subjects with type 1 diabetes.
Journal
Clinical immunology (Orlando, Fla.)
ISSN: 1521-7035
Titre abrégé: Clin Immunol
Pays: United States
ID NLM: 100883537
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
04
09
2019
revised:
27
11
2019
accepted:
29
11
2019
pubmed:
7
12
2019
medline:
5
8
2020
entrez:
7
12
2019
Statut:
ppublish
Résumé
IL-6 is a pro-inflammatory cytokine upregulated in some autoimmune diseases. The role of IL-6 in the development of type 1 diabetes (T1D) is unclear. Clinical studies are investigating whether tocilizumab (anti-IL-6 receptor) can help preserve beta cell function in patients recently diagnosed with T1D. However, in some rodent models and isolated human islets, IL-6 has been found to have a protective role for beta cells by reducing oxidative stress. Hence, we systematically investigated local tissue expression of IL-6 in human pancreas from non-diabetic, auto-antibody positive donors and donors with T1D and T2D. IL-6 was constitutively expressed by beta and alpha cells regardless of the disease state. However, expression of IL-6 was highly reduced in insulin-deficient islets of donors with T1D, and the expression was then mostly restricted to alpha cells. Our findings suggest that the implication of IL-6 in T1D pathogenesis might be more complex than previously assumed.
Identifiants
pubmed: 31809899
pii: S1521-6616(19)30479-6
doi: 10.1016/j.clim.2019.108320
pmc: PMC6961707
mid: NIHMS1547447
pii:
doi:
Substances chimiques
IL6 protein, human
0
Interleukin-6
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108320Subventions
Organisme : NIAID NIH HHS
ID : R01 AI092453
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI134971
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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