Food-Derived Compounds Apigenin and Luteolin Modulate mRNA Splicing of Introns with Weak Splice Sites.
Molecular Biology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
20 Dec 2019
20 Dec 2019
Historique:
received:
26
07
2019
revised:
23
10
2019
accepted:
15
11
2019
pubmed:
7
12
2019
medline:
7
12
2019
entrez:
7
12
2019
Statut:
ppublish
Résumé
Cancer cells often exhibit extreme sensitivity to splicing inhibitors. We identified food-derived flavonoids, apigenin and luteolin, as compounds that modulate mRNA splicing at the genome-wide level, followed by proliferation inhibition. They bind to mRNA splicing-related proteins to induce a widespread change of splicing patterns in treated cells. Their inhibitory activity on splicing is relatively moderate, and introns with weak splice sites tend to be sensitive to them. Such introns remain unspliced, and the resulting intron-containing mRNAs are retained in the nucleus, resulting in the nuclear accumulation of poly(A)
Identifiants
pubmed: 31809999
pii: S2589-0042(19)30483-3
doi: 10.1016/j.isci.2019.11.033
pmc: PMC6909097
pii:
doi:
Types de publication
Journal Article
Langues
eng
Pagination
336-352Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.
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