Simplified monomeric VHH-Fc antibodies provide new opportunities for passive immunization.

Antibodies, Monoclonal Communicable Diseases Humans Immunization, Passive Immunoglobulin Fc Fragments

Journal

Current opinion in biotechnology
ISSN: 1879-0429
Titre abrégé: Curr Opin Biotechnol
Pays: England
ID NLM: 9100492

Informations de publication

Date de publication:
02 2020
Historique:
received: 03 09 2019
revised: 31 10 2019
accepted: 04 11 2019
pubmed: 7 12 2019
medline: 28 8 2020
entrez: 7 12 2019
Statut: ppublish

Résumé

Simplified monomeric monoclonal antibodies consisting of a single-domain VHH, derived from camelid heavy-chain only antibodies, fused with the Fc domain of either IgG (VHH-IgG) or IgA (VHH-IgA) antibodies, are promising therapeutic proteins. These simplified single-gene encoded antibodies are much easier to manufacture and can be produced in plants and in yeast for bulk applications. These merits enable novel passive immunization applications, such as in-feed oral delivery of VHH-IgAs, which have successfully provided protection against a gastrointestinal infection in the piglet model.

Identifiants

DOI: 10.1016/j.copbio.2019.11.006 PMID: 31810049
pubmed: 31810049
pii: S0958-1669(19)30116-8
doi: 10.1016/j.copbio.2019.11.006
pii:
doi:

Substances chimiques

Antibodies, Monoclonal 0
Immunoglobulin Fc Fragments 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

96-101

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Henri De Greve (H)

Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium; VIB Center for Structural Biology, 1050 Brussels, Belgium.

Vikram Virdi (V)

Department of Biochemistry and Microbiology, Ghent University, 9000 Gent, Belgium; VIB Center for Medical Biotechnology, 9052 Gent, Belgium.

Shruti Bakshi (S)

Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Gent, Belgium; VIB Center for Plant Systems Biology, 9052 Gent, Belgium.

Ann Depicker (A)

Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Gent, Belgium; VIB Center for Plant Systems Biology, 9052 Gent, Belgium. Electronic address: anna.depicker@ugent.be.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Simplified monomeric VHH-Fc antibodies provide...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladies transmissibles › Simplified monomeric VHH-Fc antibodies provide...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Simplified monomeric VHH-Fc antibodies provide...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunisation passive › Simplified monomeric VHH-Fc antibodies provide...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Fragments d'immunoglobuline › Fragments Fc des immunoglobulines › Simplified monomeric VHH-Fc antibodies provide...