The Right Time to Safely Re-Evaluate Empirical Antimicrobial Treatment of Hip or Knee Prosthetic Joint Infections.
bacterial growth time
empirical antimicrobial treatment
postoperative antibiotics
prosthetic joint infection
time to positivity
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
02 Dec 2019
02 Dec 2019
Historique:
received:
18
10
2019
revised:
28
11
2019
accepted:
29
11
2019
entrez:
8
12
2019
pubmed:
8
12
2019
medline:
8
12
2019
Statut:
epublish
Résumé
Currently, no guideline provides recommendations on the duration of empirical antimicrobial treatment (EAT) in prosthetic joint infection (PJI). The aim of our study was to describe the time to growth of bacteria involved in PJI, rendering possible decreased duration of EAT. Based on a French multicentre prospective cohort study, culture data from patients with confirmed hip or knee PJI were analysed. For each patient, five samples were processed. Time to positivity was defined as the first positive medium in at least one sample for virulent pathogens and as the first positive medium in at least two samples for commensals. Definitive diagnosis of polymicrobial infections was considered the day the last bacteria were identified. Among the 183 PJIs, including 28 polymicrobial infections, microbiological diagnosis was carried out between Day 1 (D1) and D5 for 96.7% of cases. There was no difference in the average time to positivity between acute and chronic PJI (
Identifiants
pubmed: 31810267
pii: jcm8122113
doi: 10.3390/jcm8122113
pmc: PMC6947470
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : French Ministry of Health (Programme Hospitalier de Recherche Clinique Interrégionale)
ID : API/N/041
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