Glycerol kinase enhances hepatic lipid metabolism by repressing nuclear receptor subfamily 4 group A1 in the nucleus.
Animals
Cell Nucleus
/ metabolism
Diabetes Mellitus, Experimental
/ metabolism
Gene Expression Regulation
Glucose
/ metabolism
Glycerol Kinase
/ metabolism
HEK293 Cells
Homeostasis
Humans
Ligands
Lipid Metabolism
Liver
/ metabolism
Male
Mice
Mice, Inbred C57BL
Nuclear Receptor Subfamily 4, Group A, Member 1
/ metabolism
Protein Isoforms
Triglycerides
/ metabolism
Up-Regulation
NR4A1
diabetes
diabète
feed-forward regulation
glycerol kinase
glycérol kinase
lipid metabolism
métabolisme des lipides
régulation ouverte
Journal
Biochemistry and cell biology = Biochimie et biologie cellulaire
ISSN: 1208-6002
Titre abrégé: Biochem Cell Biol
Pays: Canada
ID NLM: 8606068
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
pubmed:
10
12
2019
medline:
25
2
2021
entrez:
10
12
2019
Statut:
ppublish
Résumé
Glycerol kinase (GYK) plays a critical role in hepatic metabolism by converting glycerol to glycerol 3-phosphate in an ATP-dependent reaction. GYK isoform b is the only glycerol kinase present in whole cells, and has a non-enzymatic moonlighting function in the nucleus. GYK isoform b acts as a co-regulator of nuclear receptor subfamily 4 group A1 (NR4A1) and participates in the regulation of hepatic glucose metabolism by protein-protein interaction with NR4A1. Herein, GYK expression was found to upregulate the expression of NR4A1-mediated lipid metabolism-related genes (
Identifiants
pubmed: 31813231
doi: 10.1139/bcb-2019-0317
doi:
Substances chimiques
Ligands
0
NR4A1 protein, human
0
Nr4a1 protein, mouse
0
Nuclear Receptor Subfamily 4, Group A, Member 1
0
Protein Isoforms
0
Triglycerides
0
Glycerol Kinase
EC 2.7.1.30
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM