Neuromuscular Diseases of the Newborn.
Journal
Seminars in pediatric neurology
ISSN: 1558-0776
Titre abrégé: Semin Pediatr Neurol
Pays: United States
ID NLM: 9441351
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
entrez:
10
12
2019
pubmed:
10
12
2019
medline:
10
7
2020
Statut:
ppublish
Résumé
The peripheral nervous system (PNS) is composed of motor neurons, nerve roots, plexuses, peripheral nerves (motor, sensory and autonomic), neuromuscular junction, and skeletal muscles. Disorders of the PNS in neonates most frequently cause weakness, hypotonia, and contractures, which may be generalized or focal. Since these findings may also occur with brain and spinal cord lesions, key features of the history and neurologic exam, together with diagnostic testing, are helpful in reaching a diagnosis. This review covers the diagnostic approach to PNS disorders in the neonate and includes a discussion of representative diseases of the motor neuron, brachial plexus, peripheral nerves, neuromuscular junction, and muscles. The importance of reaching a precise genetic diagnosis is highlighted with a discussion of current and emerging treatments for neonatal PNS diseases, particularly spinal muscular atrophy.
Identifiants
pubmed: 31813523
pii: S1071-9091(19)30078-6
doi: 10.1016/j.spen.2019.08.007
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
100771Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.