TwoLumps Ascending Neurons Mediate Touch-Evoked Reversal of Walking Direction in Drosophila.
Drosophila
ascending neuron
backward walking
behavior
descending neuron
locomotion
mechanosensation
sensorimotor transformation
Journal
Current biology : CB
ISSN: 1879-0445
Titre abrégé: Curr Biol
Pays: England
ID NLM: 9107782
Informations de publication
Date de publication:
16 12 2019
16 12 2019
Historique:
received:
08
06
2019
revised:
09
10
2019
accepted:
01
11
2019
pubmed:
10
12
2019
medline:
18
8
2020
entrez:
10
12
2019
Statut:
ppublish
Résumé
External cues, including touch, enable walking animals to flexibly maneuver around obstacles and extricate themselves from dead-ends (for reviews, see [1-3]). In a screen for neurons that enable Drosophila melanogaster to retreat when it encounters a dead-end, we identified a pair of ascending neurons, the TwoLumps Ascending (TLA) neurons. Silencing TLA activity impairs backward locomotion, whereas optogenetic activation triggers backward walking. TLA-induced reversal is mediated in part by the Moonwalker Descending Neurons (MDNs) [4], which receive excitatory input from the TLAs. Silencing the TLAs decreases the extent to which freely walking flies back up upon encountering a physical barrier in the dark, and TLAs show calcium responses to optogenetic activation of neurons expressing the mechanosensory channel NOMPC. We infer that TLAs convey feedforward mechanosensory stimuli to transiently activate MDNs in response to anterior body touch.
Identifiants
pubmed: 31813606
pii: S0960-9822(19)31443-5
doi: 10.1016/j.cub.2019.11.004
pii:
doi:
Substances chimiques
Drosophila Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4337-4344.e5Subventions
Organisme : Howard Hughes Medical Institute
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.