Evaluation of crude saponins, methanolic extract and subsequent fractions from Isodon rugosus Wall. ex Benth: Potentials of anti-angiogenesis in egg and anti-tumorigenesis in potato.


Journal

Pakistan journal of pharmaceutical sciences
ISSN: 1011-601X
Titre abrégé: Pak J Pharm Sci
Pays: Pakistan
ID NLM: 9426356

Informations de publication

Date de publication:
Sep 2019
Historique:
entrez: 10 12 2019
pubmed: 10 12 2019
medline: 28 4 2020
Statut: ppublish

Résumé

Based on the ethnomedicinal use of Isodon rugosus the current study was designed to evaluate its crude saponins (Ir.Sp), and subsequent fractions for anti-angiogenic and anti-tumor potentials. Chorioallantoic membrane (CAM) assay was used in anti-angiogenic potentials with Dexamethasone as positive control. The antitumor activity was evaluated with potato disk method using Vincristine sulfate as positive control. Moreover, antibacterial activity was also conducted against A. tumefaciens. The highest anti-angiogenic effect was observed with Ir.Sp, i.e., 79.00±0.58% at concentration of 1000 μg/ml which drop drown to 48.67±1.20% at lowest tested concentration of 31.25 μg/ml with IC

Identifiants

pubmed: 31813860

Substances chimiques

Anti-Bacterial Agents 0
Antineoplastic Agents 0
Plant Extracts 0
Saponins 0
Methanol Y4S76JWI15

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1971-1977

Auteurs

Abdul Sadiq (A)

Department of Pharmacy, University of Malakand, Chakdara, Dir (L), KP, Pakistan.

Anwar Zeb (A)

Department of Pharmacy, University of Malakand, Chakdara, Dir (L), KP, Pakistan.

Sajjad Ahmad (S)

Department of Pharmacy, University of Malakand, Chakdara, Dir (L), KP, Pakistan.

Farhat Ullah (F)

Department of Pharmacy, University of Malakand, Chakdara, Dir (L), KP, Pakistan.

Muhammad Ayaz (M)

Department of Pharmacy, University of Malakand, Chakdara, Dir (L), KP, Pakistan.

Farman Ullah (F)

Department of Pharmacy, Kohat University of Science & Technology, Kohat, KP, Pakistan.

Nawab Ali (N)

Department of Biotechnology, Kohat University of Science & Technology, Kohat, KP, Pakistan.

Jamshaid Ahmad (J)

Centre of Biotechnology and Microbiology, University of Peshawar, KP, Pakistan.

Farhan A Khan (FA)

Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad, KP, Pakistan.

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Classifications MeSH