Theranostic markers for personalized therapy of spider phobia: Methods of a bicentric external cross-validation machine learning approach.
machine learning
spider phobia
theranostic markers
Journal
International journal of methods in psychiatric research
ISSN: 1557-0657
Titre abrégé: Int J Methods Psychiatr Res
Pays: United States
ID NLM: 9111433
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
09
05
2019
revised:
18
09
2019
accepted:
08
10
2019
pubmed:
10
12
2019
medline:
29
6
2021
entrez:
10
12
2019
Statut:
ppublish
Résumé
Embedded in the Collaborative Research Center "Fear, Anxiety, Anxiety Disorders" (CRC-TRR58), this bicentric clinical study aims at identifying biobehavioral markers of treatment (non-)response by applying machine learning methodology with an external cross-validation protocol. We hypothesize that a priori prediction of treatment (non-)response is possible in a second, independent sample based on multimodal markers. One-session virtual reality exposure treatment (VRET) with patients with spider phobia was conducted on two sites. Clinical, neuroimaging, and genetic data were assessed at baseline, post-treatment and after 6 months. The primary and secondary outcomes defining treatment response are as follows: 30% reduction regarding the individual score in the Spider Phobia Questionnaire and 50% reduction regarding the individual distance in the behavioral avoidance test. N = 204 patients have been included (n = 100 in Würzburg, n = 104 in Münster). Sample characteristics for both sites are comparable. This study will offer cross-validated theranostic markers for predicting the individual success of exposure-based therapy. Findings will support clinical decision-making on personalized therapy, bridge the gap between basic and clinical research, and bring stratified therapy into reach. The study is registered at ClinicalTrials.gov (ID: NCT03208400).
Identifiants
pubmed: 31814209
doi: 10.1002/mpr.1812
pmc: PMC7301283
doi:
Substances chimiques
Biomarkers
0
Banques de données
ClinicalTrials.gov
['NCT03208400']
Types de publication
Clinical Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1812Informations de copyright
© 2019 The Authors. International Journal of Methods in Psychiatric Research Published by John Wiley & Sons Ltd.
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