N-Heterocyclic Carbene Catalyzed Photoenolization/Diels-Alder Reaction of Acid Fluorides.

N-heterocyclic carbenes acid fluorides organocatalysis photochemistry photoenolization

Journal

Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543

Informations de publication

Date de publication:
17 Feb 2020
Historique:
received: 12 11 2019
pubmed: 10 12 2019
medline: 10 12 2019
entrez: 10 12 2019
Statut: ppublish

Résumé

The combination of light activation and N-heterocyclic carbene (NHC) organocatalysis has enabled the use of acid fluorides as substrates in a UVA-light-mediated photochemical transformation previously observed only with aromatic aldehydes and ketones. Stoichiometric studies and TD-DFT calculations support a mechanism involving the photoactivation of an ortho-toluoyl azolium intermediate, which exhibits "ketone-like" photochemical reactivity under UVA irradiation. Using this photo-NHC catalysis approach, a novel photoenolization/Diels-Alder (PEDA) process was developed that leads to diverse isochroman-1-one derivatives.

Identifiants

pubmed: 31814280
doi: 10.1002/anie.201914456
pmc: PMC7027522
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3190-3194

Subventions

Organisme : Deutsche Forschungsgemeinschaft
ID : 420535461
Organisme : Deutsche Forschungsgemeinschaft
ID : 393271229
Organisme : Deutsche Forschungsgemeinschaft
ID : GRK 1582
Organisme : Verband der Chemischen Industrie
ID : Sachkostenzuschuss

Informations de copyright

© 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

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Auteurs

Andreas Mavroskoufis (A)

Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 3, 14195, Berlin, Germany.

Keerthana Rajes (K)

Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 3, 14195, Berlin, Germany.

Paul Golz (P)

Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 3, 14195, Berlin, Germany.

Arush Agrawal (A)

Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 3, 14195, Berlin, Germany.

Vincent Ruß (V)

Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 3, 14195, Berlin, Germany.

Jan P Götze (JP)

Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 3, 14195, Berlin, Germany.

Matthew N Hopkinson (MN)

Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 3, 14195, Berlin, Germany.

Classifications MeSH