Influence of placebo effects on quality of life and wound healing in patients with chronic venous leg ulcers.
Journal
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
ISSN: 1610-0387
Titre abrégé: J Dtsch Dermatol Ges
Pays: Germany
ID NLM: 101164708
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
22
03
2019
accepted:
18
08
2019
pubmed:
10
12
2019
medline:
15
12
2020
entrez:
10
12
2019
Statut:
ppublish
Résumé
Placebo effects are used in the treatment of various medical conditions. To date, there is little scientific data in this regard as it relates to skin diseases in general and hardly any data with respect to wound healing in particular. In a prospective randomized controlled trial, patients with chronic venous leg ulcers were observed for a period of 14 weeks. The objective was to investigate whether raising patients' expectations with regard to a novel wound treatment might have an effect on wound healing processes as well as wound-related quality of life, anxiety, depression and pain. Overall, 20 patients were included in the trial. They were stratified based on gender and randomized to either the intervention (IG) or the control group (CG). In both groups, the wound area decreased significantly over the course of the observation period. Unlike patients in the CG, those in the IG experienced significant improvement in wound-related quality of life (wound-QoL) in terms of both the overall score and the various subscales. Neither group showed significant changes with respect to pain, anxiety and depression. Our study is the first to show that - merely by raising patients' expectations for a novel treatment - placebo effects can significantly improve quality of life in patients with chronic venous leg ulcers. In the future, our findings should be integrated into the development of treatment concepts for patients with chronic wounds and should be investigated in larger cohorts.
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
103-109Informations de copyright
© 2019 The Authors. Journal der Deutschen Dermatologischen Gesellschaft published by John Wiley & Sons Ltd on behalf of Deutsche Dermatologische Gesellschaft.
Références
Dissemond J, Bültemann A, Gerber V et al. Definitionen für die Wundbehandlung. Hautarzt 2016; 67: 265-6.
Dissemond J, Körber A, Grabbe S. Differentialdiagnosen des Ulcus cruris. J Dtsch Dermatol Ges 2006; 4: 627-34.
Kiecolt-Glaser JK, Marucha PT, Malarkey WB et al. Slowing of wound healing by psychological stress. Lancet 1995; 346(8984): 1194-6.
Glaser R, Kiecolt-Glaser JK. Stress-induced immune dysfunction: implications for health. Nat Rev Immunol 2005; 5(3): 243-51.
Ader R, Mercurio MG, Walton J et al. Conditioned pharmacotherapeutic effects: a preliminary study. Psychosom Med 2010; 72(2): 192-7.
Enck P, Bingel U, Schedlowski M, Rief W. The placebo response in medicine: minimize, maximize or personalize? Nat Rev Drug Discov 2013; 12: 191-204.
Schedlowski M, Enck P, Rief W, Bingel U. Neuro-bio-behavioral mechanisms of placebo and nocebo responses: Implications for clinical trials and clinical practice. Pharmacol Rev 2015; 67: 697-730.
Wager TD, Atlas LY. The neuroscience of placebo effects: connecting context, learning and health. Nat Rev Neurosci 2015; 16: 403-18.
Klinger R. The potential of the analgetic placebo effect - S3-guideline recommendation on the clinical use for acute and perioperative pain management. Anasthesiol Intensivmed Notfallmed Schmerzther 2010; 45: 22-9.
Evers AW. Using the placebo effect: how expectations and learned immune function can optimize dermatological treatments. Exp Dermatol 2017; 26: 18-21.
Goebel MU, Meykadeh N, Kou W et al. Behavioral conditioning of antihistamine effects in patients with allergic rhinitis. Psychother Psychosom 2008; 77(4): 227-34.
Vits S, Cesko E, Benson S et al. Cognitive factors mediate placebo responses in patients with house dust mite allergy. PLoS One 2013; 8(11): e79576.
Hadamitzky M, Sondermann W, Benson S, Schedlowski M. Placebo effects in the immune system. In: Colloca L (ed.). Neurobiology of the placebo effect. Int Rev Neurobiol 2018; 138: 39-59.
Sölle A, Bartholomäus T, Worm M, Klinger R. How to psychologically minimize scratching impulses benefits of placebo effects on itching using classical conditioning and expectancy. Z Psychol 2014; 222(3): 140-7.
vonLaarhoven AIM, van der Sman-Mauriks IM, Donders ART et al. Placebo effects on itch: a meta-analysis of clinical trials of patients with dermatological conditions. J Invest Dermatol 2015; 135: 1234-43.
Blome C, Baade K, Debus ES et al. The “Wound-QoL”: a short questionnaire measuring quality of life in patients with chronic wounds based on three established disease-specific instruments. Wound Repair Regen 2014; 22(4): 504-14.
Herrmann-Lingen C, Buss U, Snaith R. Hospital anxiety and depression scale - German Version. Huber Verlag, Bern 2005.
Larbig W, Fallert B, de Maddalena H. Tumorschmerz: Interdisziplinäre Therapiekonzepte. 2. Auflage, Schattauer Verlag, 2002: 186-7.
Kaptchuk TJ, Kelley JM, Conboy LA et al. Components of placebo effect: randomised controlled trial in patients with irritable bowel syndrome. BMJ 2008; 336: 999-1003.
Petrie KJ, Rief W. Psychobiological mechanisms of placebo and nocebo effects: Pathways to improve treatments and reduce side effects. Annu Rev Psychol 2019; 70: 599-625.
Vits S, Dissemond J, Schadendorf D et al. Expectation-induced placebo responses fail to accelerate wound healing in healthy volunteers: results from a prospective controlled experimental trial. Int Wound J 2015; 12: 664-8.
Walburn J, Vedhara K, Hankins M et al. Psychological stress and wound healing in humans: a systematic review and meta-analysis. J Psychosom Res 2009; 67: 253-71.
Jockenhöfer F, Gollnick H, Herberger K et al. Aetiology, comorbidities and cofactors of chronic leg ulcers: retrospective evaluation of 1000 patients from 10 specialized dermatological wound care centers in Germany. Int Wound J 2016; 13(5): 821-8.
Margolis DJ, Berlin JA, Strom BL. Which venous leg ulcers will heal with limb bandages? Am J Med 2000; 109: 9-15.
Moseley JB, O'Malley K, Petersen NJ et al. A controlled trial of arthroscopic surgery for osteoarthritis of the knee. N Engl J Med 2002; 347(2): 81-8.
Wartolowska K, Judge A, Hopewell S et al. Use of placebo controls in the evaluation of surgery: systematic review. BMJ 2014; 348: 3253.
Snippen NC, de Vries HJ, van der Burg-Vermeulen SJ et al. Influence of significant others on work participation of individuals with chronic diseases: a systematic review. BMJ Open 2019; 9(1): 021742.