Hypothyroidism is Not Associated with Keratoconus Disease: Analysis of 626 Subjects.
Journal
Journal of ophthalmology
ISSN: 2090-004X
Titre abrégé: J Ophthalmol
Pays: United States
ID NLM: 101524199
Informations de publication
Date de publication:
2019
2019
Historique:
received:
02
04
2019
revised:
04
09
2019
accepted:
21
09
2019
entrez:
10
12
2019
pubmed:
10
12
2019
medline:
10
12
2019
Statut:
epublish
Résumé
To analyze the association between hypothyroidism and keratoconus, we examined blood thyroid hormone levels and corneal tomographic parameters in healthy subjects and patients with keratoconus. We included 626 subjects (304 left eyes, 49%; 431 males, 69%; age 38.4 ± 14.3 y). Patients with keratoconus were from our Homburg Keratoconus Center (HKC) ( Previous thyroid medication, previous ocular surgery, and patients with suspected keratoconus (topographic keratoconus classification, [TKC]: 0 < 1). Patient eyes were classified (TKC) with dedicated, instrument-based, keratoconus detection software provided with the Pentacam. TKC = 0 was considered "normal," and TKCs ≥ 1 were considered keratoconus. Subjects were also classified as euthyroid or hypothyroid, based on blood thyroid hormone status (i.e., TSH, FT3, and FT4). A multiple logistic linear regression model was constructed to determine the effects of age (covariate), gender, and hypothyroidism (effect sizes) on "TKC-positive" disease. The significance levels for a constant parameter, sex, thyroid condition, and age were Keratoconus appeared to occur more often in patients classified as euthyroid than in patients with hypothyroidism. Thus, hypothyroidism alone could not support the development of keratoconus. Based on these results, it should not be mandatory to screen patients with hypothyroidism for keratoconus or patients with keratoconus for hypothyroidism.
Identifiants
pubmed: 31815013
doi: 10.1155/2019/3268595
pmc: PMC6877948
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3268595Informations de copyright
Copyright © 2019 Zsuzsa Flaskó et al.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest related to this study.
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