Type 2 Diabetes Mellitus Increases the Risk to Hip Fracture in Postmenopausal Osteoporosis by Deteriorating the Trabecular Bone Microarchitecture and Bone Mass.
Animals
Bone Density
Cancellous Bone
/ diagnostic imaging
Diabetes Mellitus, Experimental
/ metabolism
Diabetes Mellitus, Type 2
/ epidemiology
Female
Femur Head
/ diagnostic imaging
Hip Fractures
/ epidemiology
Humans
Osteoporosis
/ diagnostic imaging
Osteoporosis, Postmenopausal
/ epidemiology
Osteoporotic Fractures
/ epidemiology
Ovariectomy
Postmenopause
Rats
Risk Factors
X-Ray Microtomography
Journal
Journal of diabetes research
ISSN: 2314-6753
Titre abrégé: J Diabetes Res
Pays: England
ID NLM: 101605237
Informations de publication
Date de publication:
2019
2019
Historique:
received:
04
08
2019
revised:
10
09
2019
accepted:
03
10
2019
entrez:
10
12
2019
pubmed:
10
12
2019
medline:
11
6
2020
Statut:
epublish
Résumé
T2DM is linked to an increase in the fracture rate as compared to the nondiabetic population even with normal or raised bone mineral density (BMD). Hence, bone quality plays an important role in the pathogenesis of skeletal fragility due to T2DM. This study analyzed the changes in the trabecular bone microstructure due to T2DM at various time points in ovariectomized and nonovariectomized rats. Animals were divided into four groups: (I) control (sham), (II) diabetic (sham), (III) ovariectomized, and (IV) ovariectomized with diabetes. The trabecular microarchitecture of the femoral head was characterized using a micro-CT. The differences between the groups were analyzed at 8, 10, and 14 weeks of the onset of T2DM using a two-way analysis of variance and by post hoc multiple comparisons. The diabetic group with and without ovariectomies demonstrated a significant increase in trabecular separation and a decrease in bone volume fraction, trabecular number, and thickness. BMD decreased in ovariectomized diabetic animals at 14 weeks of the onset of T2DM. No significant change was found in connectivity density and degree of anisotropy among groups. The structural model index suggested a change towards a weaker rod-like microstructure in diabetic animals. The data obtained suggested that T2DM affects the trabecular structure within a rat's femoral heads negatively and changes are most significant at a longer duration of T2DM, increasing the risk to hip fractures.
Identifiants
pubmed: 31815147
doi: 10.1155/2019/3876957
pmc: PMC6878775
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3876957Informations de copyright
Copyright © 2019 Sahar Mohsin et al.
Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest regarding the publication of this paper.
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