Endogenous formaldehyde is a memory-related molecule in mice and humans.

Alzheimer's disease Energy metabolism Hippocampus

Journal

Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179

Informations de publication

Date de publication:
2019
Historique:
received: 12 07 2019
accepted: 04 11 2019
entrez: 10 12 2019
pubmed: 10 12 2019
medline: 10 12 2019
Statut: epublish

Résumé

Gaseous formaldehyde is an organic small molecule formed in the early stages of earth's evolution. Although toxic in high concentrations, formaldehyde plays an important role in cellular metabolism and, unexpectedly, is found even in the healthy brain. However, its pathophysiological functions in the brain are unknown. Here, we report that under physiological conditions, spatial learning activity elicits rapid formaldehyde generation from mitochondrial sarcosine dehydrogenase (SARDH). We find that elevated formaldehyde levels facilitate spatial memory formation by enhancing N-methyl-D-aspartate (NMDA) currents, but that high formaldehyde concentrations gradually inactivate the NMDA receptor by cross-linking NR1 subunits to NR2B via the C232 residue. We also report that in mice with aldehyde dehydrogenase-2 (

Identifiants

DOI: 10.1038/s42003-019-0694-x PMID: 31815201 PMC: PMC6884489
pubmed: 31815201
doi: 10.1038/s42003-019-0694-x
pii: 694
pmc: PMC6884489
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

446

Commentaires et corrections

Type : ErratumIn

Informations de copyright

© The Author(s) 2019.

Déclaration de conflit d'intérêts

Competing interestsThe authors declare no competing interests.

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Auteurs

Li Ai (L)

1Alzheimer's Disease Center, Beijing Institute for Brain Disorders; Center for Brain Disorders Research, Capital Medical University, Beijing, 100069 China.

Tao Tan (T)

2Department of Physiology and Biophysics School of Medicine & Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14214 USA.
Sichuan Provincial Hospital for Women and Children, Chengdu, 610000 China.
ORCID: 0000-0002-4571-3296

Yonghe Tang (Y)

4Institute of Fluorescent Probes for Biological Imaging, School of Chemistry and Chemical Engineering, School of Materials Science and Engineering, University of Jinan, Shandong, 250022 China.

Jun Yang (J)

5Department of Radiology, Peking University Third Hospital, Beijing, China.
Key Laboratory of Magnetic Resonance Imaging Equipment and Technique, Beijing, 100191 China.

Dehua Cui (D)

5Department of Radiology, Peking University Third Hospital, Beijing, China.
Key Laboratory of Magnetic Resonance Imaging Equipment and Technique, Beijing, 100191 China.

Rui Wang (R)

5Department of Radiology, Peking University Third Hospital, Beijing, China.
Key Laboratory of Magnetic Resonance Imaging Equipment and Technique, Beijing, 100191 China.

Aibo Wang (A)

5Department of Radiology, Peking University Third Hospital, Beijing, China.
Key Laboratory of Magnetic Resonance Imaging Equipment and Technique, Beijing, 100191 China.

Xuechao Fei (X)

1Alzheimer's Disease Center, Beijing Institute for Brain Disorders; Center for Brain Disorders Research, Capital Medical University, Beijing, 100069 China.

Yalan Di (Y)

1Alzheimer's Disease Center, Beijing Institute for Brain Disorders; Center for Brain Disorders Research, Capital Medical University, Beijing, 100069 China.

Xiaoming Wang (X)

1Alzheimer's Disease Center, Beijing Institute for Brain Disorders; Center for Brain Disorders Research, Capital Medical University, Beijing, 100069 China.

Yan Yu (Y)

7Beijing Boai Hospital, China Rehabilitation Research Center, Beijing, 100068 China.

Shengjie Zhao (S)

7Beijing Boai Hospital, China Rehabilitation Research Center, Beijing, 100068 China.

Weishan Wang (W)

4Institute of Fluorescent Probes for Biological Imaging, School of Chemistry and Chemical Engineering, School of Materials Science and Engineering, University of Jinan, Shandong, 250022 China.

Shangying Bai (S)

1Alzheimer's Disease Center, Beijing Institute for Brain Disorders; Center for Brain Disorders Research, Capital Medical University, Beijing, 100069 China.
8Department of Physiology, Southern Illinois University School of Medicine, Carbondale, IL 62901 USA.

Xu Yang (X)

9Section of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Sciences, Central China Normal University, Wuhan, 430079 China.
ORCID: 0000-0001-8015-6299

Rongqiao He (R)

1Alzheimer's Disease Center, Beijing Institute for Brain Disorders; Center for Brain Disorders Research, Capital Medical University, Beijing, 100069 China.
10State Key Laboratory of Brain & Cognitive Science, Institute of Biophysics, CAS Key Laboratory of Mental Health, University of Chinese Academy of Sciences (UCAS), Beijing, 100101 China.

Weiying Lin (W)

4Institute of Fluorescent Probes for Biological Imaging, School of Chemistry and Chemical Engineering, School of Materials Science and Engineering, University of Jinan, Shandong, 250022 China.

Hongbin Han (H)

5Department of Radiology, Peking University Third Hospital, Beijing, China.
Key Laboratory of Magnetic Resonance Imaging Equipment and Technique, Beijing, 100191 China.

Xiang Cai (X)

8Department of Physiology, Southern Illinois University School of Medicine, Carbondale, IL 62901 USA.

Zhiqian Tong (Z)

1Alzheimer's Disease Center, Beijing Institute for Brain Disorders; Center for Brain Disorders Research, Capital Medical University, Beijing, 100069 China.

Classifications MeSH