An Isocaloric Nordic Diet Modulates
gene expression
inflammation
metabolic syndrome
peripheral blood mononuclear cells
randomized controlled dietary intervention
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
03 Dec 2019
03 Dec 2019
Historique:
received:
30
10
2019
revised:
22
11
2019
accepted:
27
11
2019
entrez:
11
12
2019
pubmed:
11
12
2019
medline:
1
7
2020
Statut:
epublish
Résumé
A healthy dietary pattern is associated with a lower risk of metabolic syndrome (MetS) and reduced inflammation. To explore this at the molecular level, we investigated the effect of a Nordic diet (ND) on changes in the gene expression profiles of inflammatory and lipid-related genes in peripheral blood mononuclear cells (PBMCs) of individuals with MetS. We hypothesized that the intake of an ND compared to a control diet (CD) would alter the expression of inflammatory genes and genes involved in lipid metabolism. The individuals with MetS underwent an 18/24-week randomized intervention to compare a ND with a CD. Eighty-eight participants (66% women) were included in this sub-study of the larger SYSDIET study. Fasting PBMCs were collected before and after the intervention and changes in gene expression levels were measured using TaqMan Array Micro Fluidic Cards. Forty-eight pre-determined inflammatory and lipid related gene transcripts were analyzed. The expression level of the gene tumor necrosis factor (TNF) receptor superfamily member 1A
Identifiants
pubmed: 31816875
pii: nu11122932
doi: 10.3390/nu11122932
pmc: PMC6950764
pii:
doi:
Substances chimiques
MAS1 protein, human
0
Proto-Oncogene Mas
0
RELA protein, human
0
Receptors, Tumor Necrosis Factor, Type I
0
TNFRSF1A protein, human
0
Transcription Factor RelA
0
Types de publication
Journal Article
Multicenter Study
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NordForsk
ID : 070014
Références
Hepatology. 2013 Feb;57(2):566-76
pubmed: 22941955
J Intern Med. 2014 Nov;276(5):498-511
pubmed: 24641624
Ann Nutr Metab. 2011;58(2):133-40
pubmed: 21540583
J Am Coll Nutr. 2018 Aug;37(6):457-465
pubmed: 29652564
Eur J Nutr. 2009 Dec;48(8):447-55
pubmed: 19506932
Am J Clin Nutr. 2015 Jan;101(1):228-39
pubmed: 25527767
Circulation. 2009 Oct 20;120(16):1640-5
pubmed: 19805654
J Nutr. 2012 Jul;142(7):1219-25
pubmed: 22623392
Mol Nutr Food Res. 2019 Apr 9;:e1801405
pubmed: 30964598
J Nutr Biochem. 2017 Mar;41:34-41
pubmed: 28038359
JAMA. 2004 Sep 22;292(12):1440-6
pubmed: 15383514
Mol Nutr Food Res. 2012 Jul;56(7):1160-72
pubmed: 22610960
Diabetologia. 2008 Nov;51(11):2060-7
pubmed: 18758745
J Clin Invest. 2005 May;115(5):1111-9
pubmed: 15864338
Diabetes. 2014 Jul;63(7):2356-68
pubmed: 24550191
Am Heart J. 2004 Jan;147(1):106-12
pubmed: 14691427
Br J Nutr. 2016 Oct;116(8):1383-1393
pubmed: 27737722
Mol Nutr Food Res. 2014 Apr;58(4):808-20
pubmed: 24170299
Am J Clin Nutr. 2019 May 1;109(5):1239-1250
pubmed: 31051508
Mol Nutr Food Res. 2012 Oct;56(10):1501-10
pubmed: 22961907
Am J Physiol Endocrinol Metab. 2013 Dec 1;305(11):E1375-83
pubmed: 24105415
J Clin Endocrinol Metab. 2019 Dec 1;104(12):6207-6219
pubmed: 31369090
Mol Nutr Food Res. 2014 Aug;58(8):1708-20
pubmed: 24449395
Eur Cytokine Netw. 2006 Mar;17(1):4-12
pubmed: 16613757
J Intern Med. 2013 Jul;274(1):52-66
pubmed: 23398528
J Clin Invest. 2003 Dec;112(12):1785-8
pubmed: 14679172
Genes Nutr. 2016 Mar 17;11:3
pubmed: 27482295
Am J Clin Nutr. 2007 Nov;86(5):1515-23
pubmed: 17991667
Am J Clin Nutr. 2012 May;95(5):1003-12
pubmed: 22492369