Optimizing Water-Based Extraction of Bioactive Principles of Hawthorn: From Experimental Laboratory Research to Homemade Preparations.
extraction mode
flavonoid
granulometry
hawthorn
infusion
polyphenol
procyanidin
standardization
water-based extraction
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
03 Dec 2019
03 Dec 2019
Historique:
received:
23
10
2019
revised:
13
11
2019
accepted:
27
11
2019
entrez:
11
12
2019
pubmed:
11
12
2019
medline:
25
4
2020
Statut:
epublish
Résumé
Hawthorn (Crataegus) is used for its cardiotonic, hypotensive, vasodilative, sedative, antiatherosclerotic, and antihyperlipidemic properties. One of the main goals of this work was to find a well-defined optimized extraction protocol usable by each of us that would lead to repeatable, controlled, and quantified daily uptake of active components from hawthorn at a drinkable temperature (below 60 °C). A thorough investigation of the extraction mode in water (infusion, maceration, percolation, ultrasounds, microwaves) on the yield of extraction and the amount of phenolic compounds, flavonoids, and proanthocyanidin oligomers as well as on the Ultra High Performance Liquid Chromatography (UHPLC) profiles of the extracted compounds was carried out. High-resolution Fourier transform ion cyclotron resonance mass spectrometry was also implemented to discriminate the different samples and conditions of extraction. The quantitative and qualitative aspects of the extraction as well as the kinetics of extraction were studied, not only according to the part (flowers or leaves), the state (fresh or dried), and the granulometry of the dry plant, but also the stirring speed, the temperature, the extraction time, the volume of the container (cup, mug or bowl) and the use of infusion bags.
Identifiants
pubmed: 31816956
pii: molecules24234420
doi: 10.3390/molecules24234420
pmc: PMC6930565
pii:
doi:
Substances chimiques
Flavonoids
0
Plant Extracts
0
Proanthocyanidins
0
Water
059QF0KO0R
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Campus France
ID : (PhD Fellowship)
Organisme : Ministry of Education and Training of Vietnam
ID : (PhD Fellowship)
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