SerpinB3 Differently Up-Regulates Hypoxia Inducible Factors -1α and -2α in Hepatocellular Carcinoma: Mechanisms Revealing Novel Potential Therapeutic Targets.
HCC
NEDD8
NEDDylation
SerpinB3
hypoxia
hypoxia inducible factors HIF-1α and HIF-2α
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
04 Dec 2019
04 Dec 2019
Historique:
received:
04
11
2019
revised:
29
11
2019
accepted:
02
12
2019
entrez:
11
12
2019
pubmed:
11
12
2019
medline:
11
12
2019
Statut:
epublish
Résumé
SerpinB3 (SB3) is a hypoxia and hypoxia-inducible factor (HIF)-2α-dependent cysteine-protease inhibitor up-regulated in hepatocellular carcinoma (HCC), released by cancer cells and able to stimulate proliferation and epithelial-to-mesenchymal-transition. Methods
Sections du résumé
BACKGROUND
BACKGROUND
SerpinB3 (SB3) is a hypoxia and hypoxia-inducible factor (HIF)-2α-dependent cysteine-protease inhibitor up-regulated in hepatocellular carcinoma (HCC), released by cancer cells and able to stimulate proliferation and epithelial-to-mesenchymal-transition. Methods
Identifiants
pubmed: 31817100
pii: cancers11121933
doi: 10.3390/cancers11121933
pmc: PMC6966556
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : IG 2017 Id.20361
Organisme : EITB Maratoia
ID : BIO15/CA/014
Organisme : MIUR, Rome: 776 PRIN Project
ID : 2006067527
Organisme : University of Padova
ID : CPDA110795
Organisme : SAF2017-87301-R
ID : SAF2017-87301-R
Organisme : Gobierno 779 Vasco-Departamento de Salud
ID : 2013111114
Organisme : MINECO
ID : SEV-2016-0644
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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