Novel and Rare Fusion Transcripts Involving Transcription Factors and Tumor Suppressor Genes in Acute Myeloid Leukemia.
ZEB2-BCL11B
acute myeloid leukemia
rare fusion genes
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
05 Dec 2019
05 Dec 2019
Historique:
received:
16
10
2019
revised:
15
11
2019
accepted:
02
12
2019
entrez:
11
12
2019
pubmed:
11
12
2019
medline:
11
12
2019
Statut:
epublish
Résumé
Approximately 18% of acute myeloid leukemia (AML) cases express a fusion transcript. However, few fusions are recurrent across AML and the identification of these rare chimeras is of interest to characterize AML patients. Here, we studied the transcriptome of 8 adult AML patients with poorly described chromosomal translocation(s), with the aim of identifying novel and rare fusion transcripts. We integrated RNA-sequencing data with multiple approaches including computational analysis, Sanger sequencing, fluorescence in situ hybridization and in vitro studies to assess the oncogenic potential of the
Identifiants
pubmed: 31817495
pii: cancers11121951
doi: 10.3390/cancers11121951
pmc: PMC6966504
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : European Hematology Association
ID : EHA Research Fellowship to Giorgia Simonetti
Organisme : Medical Research Council
ID : MR/R009708/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_12009
Pays : United Kingdom
Organisme : Seventh Framework Programme
ID : Grant Agreement n° 306242-NGS-PTL
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : AIRC-IG n.19226
Déclaration de conflit d'intérêts
GM has competing interests with Incyte, Celgene, Pfizer, Daiichi Sankyo. AS is employed by MLL Munich Leukemia Laboratory. CH has equity ownership of MLL Munich Leukemia Laboratory.
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