PEGylated Purpurin 18 with Improved Solubility: Potent Compounds for Photodynamic Therapy of Cancer.
PEGylated purpurin 18
apoptosis
cancer cells
cytotoxicity
flow cytometry
live-cell fluorescence microscopy
photodynamic therapy
photosensitizer
phototoxicity
singlet oxygen
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
06 Dec 2019
06 Dec 2019
Historique:
received:
30
09
2019
revised:
29
11
2019
accepted:
01
12
2019
entrez:
11
12
2019
pubmed:
11
12
2019
medline:
6
5
2020
Statut:
epublish
Résumé
Purpurin 18 derivatives with a polyethylene glycol (PEG) linker were synthesized as novel photosensitizers (PSs) with the goal of using them in photodynamic therapy (PDT) for cancer. These compounds, derived from a second-generation PS, exhibit absorption at long wavelengths; considerable singlet oxygen generation and, in contrast to purpurin 18, have higher hydrophilicity due to decreased logP. Together, these properties make them potentially ideal PSs. To verify this, we screened the developed compounds for cell uptake, intracellular localization, antitumor activity and induced cell death type. All of the tested compounds were taken up into cancer cells of various origin and localized in organelles known to be important PDT targets, specifically, mitochondria and the endoplasmic reticulum. The incorporation of a zinc ion and PEGylation significantly enhanced the photosensitizing efficacy, decreasing IC
Identifiants
pubmed: 31817655
pii: molecules24244477
doi: 10.3390/molecules24244477
pmc: PMC6943672
pii:
doi:
Substances chimiques
Porphyrins
0
Singlet Oxygen
17778-80-2
purpurin 18
25465-77-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : The Ministry of Education, Youth and Sports
ID : LO1220, LO1601, LM2015063
Organisme : CZ.02.1.01/0.0/0.0/16_013/0001799
ID : CZ.02.1.01/0.0/0.0/16_013/0001799
Organisme : OP VVV [2.16/3.1.00/24503]
ID : OP VVV [2.16/3.1.00/24503]
Organisme : Specific university research MSMT
ID : No 21-SVV/2019
Organisme : Martina Roeselová foundation
ID : Martina Roeselová foundation
Organisme : L'Oréal -UNESCO for Women in Science 2019
ID : L'Oréal -UNESCO for Women in Science 2019
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