Alternative Strategies to Inhibit Tumor Vascularization.
anti-angiogenic drugs
endothelial cells
endothelial demesenchymalization
endothelial vaccination
normalization
tumor vasculogenesis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
07 Dec 2019
07 Dec 2019
Historique:
received:
31
10
2019
revised:
26
11
2019
accepted:
04
12
2019
entrez:
11
12
2019
pubmed:
11
12
2019
medline:
2
5
2020
Statut:
epublish
Résumé
Endothelial cells present in tumors show different origin, phenotype, and genotype with respect to the normal counterpart. Various mechanisms of intra-tumor vasculogenesis sustain the complexity of tumor vasculature, which can be further modified by signals deriving from the tumor microenvironment. As a result, resistance to anti-VEGF therapy and activation of compensatory pathways remain a challenge in the treatment of cancer patients, revealing the need to explore alternative strategies to the classical anti-angiogenic drugs. In this review, we will describe some alternative strategies to inhibit tumor vascularization, including targeting of antigens and signaling pathways overexpressed by tumor endothelial cells, the development of endothelial vaccinations, and the use of extracellular vesicles. In addition, anti-angiogenic drugs with normalizing effects on tumor vessels will be discussed. Finally, we will present the concept of endothelial demesenchymalization as an alternative approach to restore normal endothelial cell phenotype.
Identifiants
pubmed: 31817884
pii: ijms20246180
doi: 10.3390/ijms20246180
pmc: PMC6940973
pii:
doi:
Substances chimiques
Angiogenesis Inhibitors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : IG2015 16973
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