Translocator protein (TSPO): the new story of the old protein in neuroinflammation.
Journal
BMB reports
ISSN: 1976-670X
Titre abrégé: BMB Rep
Pays: Korea (South)
ID NLM: 101465334
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
22
10
2019
pubmed:
11
12
2019
medline:
15
5
2020
entrez:
11
12
2019
Statut:
ppublish
Résumé
Translocator protein (TSPO), also known as peripheral benzodiazepine receptor, is a transmembrane protein located on the outer mitochondria membrane (OMM) and mainly expressed in glial cells in the brain. Because of the close correlation of its expression level with neuropathology and therapeutic efficacies of several TSPO binding ligands under many neurological conditions, TSPO has been regarded as both biomarker and therapeutic target, and the biological functions of TSPO have been a major research focus. However, recent genetic studies with animal and cellular models revealed unexpected results contrary to the anticipated biological importance of TSPO and cast doubt on the action modes of the TSPO-binding drugs. In this review, we summarize recent controversial findings on the discrepancy between pharmacological and genetic studies of TSPO and suggest some future direction to understand this old and mysterious protein. [BMB Reports 2020; 53(1): 20-27].
Substances chimiques
Ligands
0
Receptors, GABA
0
TSPO protein, human
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
20-27Références
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